The accurate determination of the spatial distribution of cardiac electrophysiological state is essential for the mechanistic assessment of cardiac arrhythmias in both clinical and experimental cardiac electrophysiological laboratories. This paper describes three fundamental cardiac source-field relationships: 1) activation fields, 2) electrotonic fields, and 3) volume conductor fields. The three cases are described analytically and illustrated with experimentally obtained canine cardiac recordings that capitalize on a recently formulated technique for in vivo cardiac transmembrane current estimation.
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http://dx.doi.org/10.1109/10.387194 | DOI Listing |
Methods Inf Med
December 2006
Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China.
Objectives: In this paper, we present a unified electrodynamic heart model that permits simulations of the body surface potentials generated by the heart in motion. The inclusion of motion in the heart model significantly improves the accuracy of the simulated body surface potentials and therefore also the 12-lead ECG.
Methods: The key step is to construct an electromechanical heart model.
Med Inform (Lond)
September 1998
Institute of Biocybernetics and Biomedical Engineering PAS, Warsaw, Poland.
In this work the investigations of the electrical field generated by the heart, carried out using a computer simulation method are presented. Two models have been constructed approximating the chest region for the following conditions: (a) normal heart activity, and (b) open chest during the cardiac surgery. For the above models the distribution of potentials on the heart surface are determined.
View Article and Find Full Text PDFIEEE Trans Biomed Eng
December 1995
Department of Biomedical Engineering, Duke University, Durham, NC 27708-0281, USA.
The central focus of this report is the evolution of transmembrane potentials following initiation of a point-source field stimulus, particularly when the stimulus is short and the stimulating electrode is close to the fiber. The transmembrane voltage threshold in response to a point-source field stimulus was determined in a numerical model of a single unmyelinated fiber. Both nerve (Hodgkin-Huxley) and cardiac (Ebihara-Johnson [1]) models of the fiber membrane were evaluated.
View Article and Find Full Text PDFIEEE Trans Biomed Eng
June 1995
University of Alberta School of Medicine, Edmonton, Canada.
The accurate determination of the spatial distribution of cardiac electrophysiological state is essential for the mechanistic assessment of cardiac arrhythmias in both clinical and experimental cardiac electrophysiological laboratories. This paper describes three fundamental cardiac source-field relationships: 1) activation fields, 2) electrotonic fields, and 3) volume conductor fields. The three cases are described analytically and illustrated with experimentally obtained canine cardiac recordings that capitalize on a recently formulated technique for in vivo cardiac transmembrane current estimation.
View Article and Find Full Text PDFAnn Biomed Eng
March 1989
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27706.
This paper reviews the evaluation of bioelectric source strength and source field relationships for excitable fibers. For the single fiber, quantitative expressions describing the source may be derived which are independent of the fields produced by the sources. Rigorous expressions describe the equivalent elemental sources as discs, while the approximate line source is frequently satisfactory under physiological conditions.
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