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Here we re-examine previous data that demonstrated lasting effects of the selective D1 receptor agonist SKF 38393, the selective D2 receptor agonist LY 171555, and of mixed SKF 39383 + LY 171555 upon striatal DA release. We demonstrate that the administration of mixed SKF 38393 + LY 171555 and of SKF 38393 administered alone induced similar time-course effects upon striatal DA release that showed significant parallel developments. We discuss these data in the light of the current literature and we suggest that D1 receptors could play a modulating role on the striatal DA activity and the release of DA in the caudate-putamen.
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| http://dx.doi.org/10.1016/0928-4257(94)90013-2 | DOI Listing |
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