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| http://dx.doi.org/10.1111/j.1440-1746.1995.tb01079.x | DOI Listing |
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Gastric ulcer in the elderly.
Ital J Gastroenterol
August 1994
Divisione di Geriatria, S.O. Schio, Italy.
Our experience shows that neither basal nor pentagastrin-stimulated acid, pepsin, pepsinogen group A and gastrin secretion significantly change across the age spectrum in subjects with peptic ulcer, even though the typical secretory patterns of patients with GU remain well-defined compared to those with duodenal ulcer (DU), even in the later decades of life. Very little is currently known about age-related changes in the various components of the gastric mucosal barrier; however, a significant reduction of the prostaglandin levels in the gastric mucosa of elderly subjects was recently reported. In elderly GU patients, the concentration of neutral glycoproteins and N-acetylneuraminic acid (NANA) was significantly higher than in young adult GU patients perhaps resulting from the migration of the border between the mucosa of the corpus and the antrum that occurs in the aged stomach.
View Article and Find Full Text PDFThe epidemiology, pathophysiology, diagnosis, clinical presentation, and treatment of peptic ulcer disease (PUD) are reviewed. PUD occurs commonly, with about 4 million Americans affected in a year. Cigarette smoking, aspirin use, and prolonged corticosteroid use are associated with PUD.
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