AI Article Synopsis
- Motoneurons in the vertebrate spinal cord are organized into columns based on the targets they connect to.
- This organization occurs early in development, but the specifics of how motoneurons identify their targets are still unclear.
- Recent research by Tsuchida et al. found that certain regulatory genes, particularly LIM-family homeobox genes, are expressed in these motor columns in chickens, potentially guiding the motoneurons to their target identities before the columns fully form.
Article Abstract
In the vertebrate spinal cord, motoneurons are clustered into longitudinal columns in agreement with the targets they innervate. Motoneurons within each column acquire properties early in development that ensure their axons navigate to appropriate targets, but how this target identity is specified is unknown. Recently, Tsuchida et al. described the expression of putative regulatory genes within motor columns in the chicken spinal cord. Combinations of LIM-family homeobox genes differentially mark columns that project to distinct target groups. Expression precedes column formation and axon outgrowth, making these genes candidates for specifying the target identity of motoneuron groups.
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| http://dx.doi.org/10.1002/bies.950170503 | DOI Listing |
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