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Brain death due to intracranial hemorrhage in a child following suspected Bothrops snakebite.
Rev Soc Bras Med Trop
December 2024
Universidade Estadual de Londrina, Departamento de Ciências Farmacêuticas, Londrina, PR, Brasil.
Snakebites from the genus Bothrops are common and are responsible for the highest mortality rate in Brazil. Factors related to the species, treatment, and patient influence the clinical manifestations and prognosis of the condition. Young patients without comorbidities have better prognoses and rarely develop severe systemic complications.
View Article and Find Full Text PDFNecrotizing Fasciitis and Streptococcal Toxic Shock Syndrome: A Case Report.
Cureus
November 2024
Department of Anesthesia, Intensive Care, and Pain Medicine, Sant'Anna and San Sebastiano Hospital, Caserta, ITA.
Group A (GAS), particularly (), is a significant human pathogen responsible for infections often ranging from mild superficial conditions to severe, life-threatening diseases like necrotizing fasciitis (NF) and streptococcal toxic shock syndrome (STSS). This case report details the rapid deterioration of a previously healthy 49-year-old woman who presented with localized symptoms in her left thigh, later escalating to septic shock and multi-organ failure related to GAS infection. Initial evaluations indicated significant inflammation and acute kidney injury, prompting broad-spectrum antibiotic treatment.
View Article and Find Full Text PDFAn Autopsy Case of Rapidly Fulminant Group A Streptococcus Infection in a Previously Healthy 67-Year-Old Woman.
Cureus
November 2024
Department of Diagnostic Pathology (DDP) and Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, Gifu, JPN.
, also known as group A (GAS), is responsible for various conditions, such as pharyngitis, tonsillitis, necrotizing fasciitis, and streptococcal toxic shock syndrome (STSS). STSS, a rapidly progressing infection involving shock and multi-organ failure, was first reported in Japan in 1992, and since then, the number of cases has been steadily increasing. We herein report an autopsy case of STSS that resulted in sudden death.
View Article and Find Full Text PDFCurrent concepts and molecular pathology of neurodegenerative diseases.
Pathology
November 2024
Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON, Canada; Laboratory Medicine Program and Krembil Brain Institute, University Health Network, Toronto, ON, Canada; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia; Edmond J. Safra Program in Parkinson's Disease, Rossy PSP Centre and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology and Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:
Neurodegenerative diseases are a pathologically, clinically and genetically diverse group of diseases characterised by selective dysfunction, loss of synaptic connectivity and neurodegeneration, and are associated with the deposition of misfolded proteins in neurons and/or glia. Molecular studies have highlighted the role of conformationally altered proteins in the pathogenesis of neurodegenerative diseases and have paved the way for developing disease-specific biomarkers that capture and differentiate the main type/s of protein abnormality responsible for neurodegenerative diseases, some of which are currently used in clinical practice. These proteins follow sequential patterns of anatomical involvement and disease spread in the brain and may also be detected in peripheral organs.
View Article and Find Full Text PDFChytridiomycosis in a colony of hellbenders Cryptobranchus alleganiensis.
J Aquat Anim Health
December 2024
Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.
Article Synopsis
- The eastern hellbender salamander is endangered and suffers from chytridiomycosis, a fungal disease primarily caused by Batrachochytrium dendrobatidis (Bd), leading to symptoms like skin shedding and death.
- At Purdue University, 33% of hellbenders experienced mortality; autopsies revealed chytridiomycosis and a co-infection with Aeromonas hydrophila.
- The outbreak was attributed to environmental stress from filtration failure; after treatment, surviving salamanders have remained healthy for over a year and were released back into the wild.
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