[The role of nonparenchymal liver cells in activating protein synthesis in hepatocytes upon stimulating the mononuclear phagocyte system with lipopolysaccharide].

It has been found that the rate of hepatocyte protein synthesis depends on the functional state of nonparenchymal liver cells (NPC), of Kupffer cells, in particular. When Kupffer cells were stimulated by intravenously injected lipopolysaccharide (LPS), zymosan or dextran sulfate, the rate of [14C]leucine incorporation into hepatic proteins increased 1.5-2-fold. Similar effects were observed in hepatocytes cocultured with NPC isolated from LPS-stimulated rats as well as in hepatocytes cultured in a conditioned medium from NPC treated with LPS, high density lipoproteins (HDL) and hydrocortisone. It is proposed that apoproteins of HDL resecreted by Kupffer cells may participate in the regulation of hepatocyte gene expression during stimulation of resident macrophages.