Objective: In recent years we have treated 4 rheumatoid arthritis (RA) patients who developed gold-induced enterocolitis, a well-recognized, although rare, complication of chrysotherapy. The aim of the present study was to seek any genetic predisposition for this complication.
Methods: HLA DNA typing was done on fresh white blood cells from the 4 patients.
Results: Three of the 4 patients (75%) exhibited the DRB1*0404 allele, whereas the prevalence of this allele among the Ashkenazi Jewish population of RA patients without colitis was 9.2% and 10.2% in 2 different studies.
Conclusion: The results indicate that the DRB1*0404 may be associated with risk for the development of gold-induced enterocolitis in this population and suggest that HLA DNA typing should be considered in Jews who may be undergoing chrysotherapy.
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Correlation between gold-induced enterocolitis and the presence of the HLA-DRB1*0404 allele.
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Objective: In recent years we have treated 4 rheumatoid arthritis (RA) patients who developed gold-induced enterocolitis, a well-recognized, although rare, complication of chrysotherapy. The aim of the present study was to seek any genetic predisposition for this complication.
Methods: HLA DNA typing was done on fresh white blood cells from the 4 patients.
Gold induced enterocolitis complicated by cytomegalovirus infection: a previously unrecognised association.
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We report on a 39-year-old male patient suffering from seropositive rheumatoid arthritis who developed severe colitis during oral gold (Auranofin) therapy. So far, two further cases of colitis during oral, and 28 cases of enterocolitis during parenteral chrysotherapy have been described. The pathomechanism has not been identified.
View Article and Find Full Text PDFA case of ulcerative proctitis complicating chrysotherapy for rheumatoid arthritis and a literature review of gold induced enterocolitis is presented. Only 26 patients have been reported with this complication. No specific therapy is available, except supportive measures and cessation of gold therapy.
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