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[A rare case of diencephalic cachexia in an adult female with cranio-pharyngioma].
Zh Vopr Neirokhir Im N N Burdenko
April 2018
Burdenko Neurosurgical Institute, Moscow, Russia.
Diencephalic cachexia (DС) is progressive weight loss despite a normal caloric intake and a satisfactory state of health, which is caused by hypothalamic lesions. This is a rare (about 100 cases were reported) and potentially fatal disorder of unknown pathogenesis. At present, there is no effective pharmacological therapy for the disorder.
View Article and Find Full Text PDFAn infant with hyperalertness, hyperkinesis, and failure to thrive: a rare diencephalic syndrome due to hypothalamic anaplastic astrocytoma.
BMC Cancer
September 2015
Neuro-oncology Unit, Department of Paediatric Medicine, Anna Meyer Children's University Hospital and Department of Health Sciences, University of Florence, Florence, Italy.
Background: Diencephalic Syndrome is a rare clinical condition of failure to thrive despite a normal caloric intake, hyperalertness, hyperkinesis, and euphoria usually associated with low-grade hypothalamic astrocytomas.
Case Presentation: We reported an unusual case of diencephalic cachexia due to hypothalamic anaplastic astrocytoma (WHO-grade III). Baseline endocrine function evaluation was performed in this patient before surgery.
Successful treatment with a low-dose cisplatin--etoposide regimen for patients with diencephalic syndrome.
J Neurooncol
September 2012
Department of Pediatric Hematology Oncology, A.O.U. Meyer Children's Hospital, viale G.Pieraccini 24, 50139, Florence, Italy.
Diencephalic syndrome (DS) is a rare but rapidly fatal condition, usually occurring during the first year of life, as a result of a hypothalamic/chiasmatic tumor. The purpose of this study was to induce an objective tumor response and to achieve rapid weight recovery by using ten three-day courses of reduced-dose cisplatin-etoposide. Between 2004 and 2009, eight pediatric patients with DS as a result of an hypothalamic tumor and with a median age at diagnosis of 6.
View Article and Find Full Text PDFCachexia secondary to intracranial anaplastic (malignant) ependymoma in a boxer dog.
J Small Anim Pract
October 2009
Department of Animal Pathology - Clinical Section, University of Turin, Via L. Da Vinci 44, 10095 Grugliasco (TO), Italy.
An eight-year-old female boxer was referred because of weight loss of several months' duration. On physical examination, cachexia was the only reported abnormality. Neurological symptoms were shown only in the last days preceding death and consisted of altered mental status, compulsive behaviour and left rear proprioception deficit.
View Article and Find Full Text PDFImprovement of diencephalic syndrome after partial surgery of optic chiasm glioma.
Pediatr Blood Cancer
September 2009
Institute of Haematology-oncology, Lyon, France.
A 10-month-old male presented with sudden growth failure and cachexia. MRI showed a chiasma of the hypothalamic mass. Biopsy was avoided due to operative risks.
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