Objective: This study was carried out in order to assess whether AS patients are adversely affected by a "good" night's sleep accompanied by little nocturnal movement.
Methods: Objective and subjective nocturnal movement, flexibility, stiffness, pain and psychomotor performance were measured in 22 subjects, 11 with ankylosing spondylitis and 11 controls.
Results: A better sleep integrity with little nocturnal movement was related to a decrease in lumbar flexibility. Difficulty in awakening and feeling tired and clumsy in the morning correlated with stiffness. Pain was correlated with a subjective difficulty in getting to sleep and a worse quality of sleep, but was also correlated with less objective sleep disruption. In the control group a better sleep integrity was correlated with an overnight decrease in psychomotor performance. In the spondylitic group a significant increase in performance occurred. Stiffness and pain did not correlate with performance.
Conclusion: Sleep in ankylosing spondylitis differs from sleep in normals.
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Background: Axial Spondyloarthritis (axSpA) is a chronic inflammatory rheumatic condition affecting the axial skeleton, leading to pain, stiffness, and fatigue. While biologic therapies have improved clinical management, many patients experience partial or no responses, resulting in delays in disease control. Additionally, the risk of adverse events and increased costs remains a concern.
View Article and Find Full Text PDFBMC Musculoskelet Disord
January 2025
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Background: Osteonecrosis of the femoral head (ONFH) is a challenging condition, primarily affecting young and middle-aged individuals, which results in hip dysfunction and, ultimately, femoral head collapse. However, the comparative effectiveness of joint-preserving procedures, particularly in the early stages of ONFH (ARCO stage I or II), remains inconclusive. This study aims to evaluate the efficacy of a novel technique called small-diameter core decompression (CD) combined with platelet-rich plasma (PRP), for the treatment of early-stage ONFH.
View Article and Find Full Text PDFInflammopharmacology
January 2025
Department of Food Technology and Nutrition, Lovely Professional University, Phagwara, Punjab, 144411, India.
Rheumatoid Arthritis (RA) is an autoimmune, chronic, systemic inflammatory disease that causes redness, swelling, stiffness, and joint pain. It is a long-lasting disease that can have a widespread impact on the body, often affecting the hands, feet, and wrists. The immune cells, such as dendritic cells, T cells, B cells, macrophages, and neutrophils, play a significant role in bone degradation and inflammation.
View Article and Find Full Text PDFACS Nano
January 2025
School of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, New South Wales 2052, Australia.
Implantable systems with chronic stability, high sensing performance, and extensive spatial-temporal resolution are a growing focus for monitoring and treating several diseases such as epilepsy, Parkinson's disease, chronic pain, and cardiac arrhythmias. These systems demand exceptional bendability, scalable size, durable electrode materials, and well-encapsulated metal interconnects. However, existing chronic implantable bioelectronic systems largely rely on materials prone to corrosion in biofluids, such as silicon nanomembranes or metals.
View Article and Find Full Text PDFTunis Med
December 2024
University of Sousse, Faculty of Medicine of Ibn ElJazzar Sousse, 4002, Farhat Hached university Hôpital, Service of rheumatology, 4031, Sousse, Tunisia.
Introduction-Aim: Postpartum septic osteoarthritis is a rare but serious condition often misdiagnosed due to overlap with common postpartum symptoms like pelvic pain and joint stiffness. This case series aims to describe the clinical, bacteriological, and radiological characteristics of postpartum septic osteoarthritis, as well as the treatment approaches and patient outcomes. Methods: A retrospective case series was conducted at Farhat Hached University Hospital, from 2006 to 2022, involving patients with confirmed postpartum septic osteoarthritis.
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