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Healthcare resource utilization and costs in immunodeficient patients receiving subcutaneous Ig: Real-world evidence from France.
PLoS One
January 2025
French National Reference Center for Primary Immunodeficiencies (CEREDIH) and Pediatric Immunology, Hematology and Rheumatology Unit, Necker Enfants Malades University Hospital, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France.
Background: Subcutaneous immunoglobulin (SCIg) replacement therapy is indicated for patients with hypogammaglobulinemia caused by primary (PID) and secondary immunodeficiencies (SID).
Objective: To compare healthcare resource utilization (HCRU) and related direct medical costs of patients in France treated with weekly conventional SCIg (cSCIg) vs monthly hyaluronidase-facilitated SCIg (fSCIg).
Methods: This retrospective study of Ig-naïve patients with PID or SID newly receiving a SCIg between 2016 and 2018, extracted from the French National Healthcare reimbursement database (SNDS), analyzed the SCIg-related HCRU and reimbursed costs generated from in-hospital (hospitalizations and SCIg doses) or at-home (nurse visits [NV] and pump provider visits [PPV], drug doses) SCIg administration.
Low-cost and scalable machine learning model for identifying children and adolescents with poor oral health using survey data: An empirical study in Portugal.
PLoS One
January 2025
Nova School of Business and Economics, Universidade Nova de Lisboa, Carcavelos, Portugal.
This empirical study assessed the potential of developing a machine-learning model to identify children and adolescents with poor oral health using only self-reported survey data. Such a model could enable scalable and cost-effective screening and targeted interventions, optimizing limited resources to improve oral health outcomes. To train and test the model, we used data from 2,133 students attending schools in a Portuguese municipality.
View Article and Find Full Text PDFBridging the gap: An outlook of oncofertility care in Africa.
Int J Gynaecol Obstet
January 2025
Department of Obstetrics and Gynecology, Aga-Khan University, Nairobi, Kenya.
This article examines existing literature on oncofertility in Africa and explores the barriers to oncofertility care. Patient-level barriers include lack of awareness about fertility preservation options, financial constraints, and the heavy emotional burden of cancer diagnosis and treatment. Healthcare-provider barriers encompass lack of awareness, prioritization of prompt cancer treatment, and implicit biases.
View Article and Find Full Text PDFThe Role of Community Organisation, Religion, Spirituality and Cultural Beliefs on Diabetes Social Support and Self-Management in Sub-Saharan Africa: Integrative Literature Review.
J Relig Health
January 2025
The Centre for Quality and Patient Safety, School of Nursing and Midwifery, Faculty of Health, Deakin University, Melbourne, Australia.
To examine the evidence for the role of community organisations, religion, spirituality, cultural beliefs, and social support in diabetes self-management, we undertook an integrative literature review utilising MEDLINE, APA PsycINFO, CINAHL, and grey literature databases. The selected articles were appraised for quality, and the extracted data were analysed thematically. The search yielded 1586 articles, and after eliminating duplicates, 1434 titles and abstracts were screened, followed by a full-text review of 103 articles.
View Article and Find Full Text PDFPrimary surgery of subcondylar mandibular fracture using patient-specific implant: the Helsinki protocol.
Oral Maxillofac Surg
January 2025
Department of Oral and Maxillofacial Diseases, Helsinki University and Helsinki University Hospital, Helsinki, Finland.
Purpose: Preoperative virtual planning and osteosynthesis with patient-specific implants (PSIs) have become a quotidian approach to many maxillofacial elective surgery setups. When a process is well-organized, a similar approach can be harnessed to serve the needs of exact primary reconstructions, especially in midfacial trauma cases. PSI osteosynthesis of the mandible is, however, more challenging because a mirror technique of the facial sides is often unreliable due to inherent lack of symmetry, and movement of the mandible increases the risk of loosening of the osteosynthesis.
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