We report the occurrence of reversible cyclosporine-induced cortical blindness in three allogeneic bone marrow transplant recipients. Possible mechanisms involved in this rare complication, as well as the associated radiographic and pathologic findings, are discussed.
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- A 29-year-old Korean woman with chronic aplastic anemia experienced seizures linked to complications from cyclosporine treatment.
- The condition was identified as posterior reversible encephalopathy syndrome due to unpredictable accumulation of the drug.
- This case highlights the importance of closely monitoring cyclosporine levels and making careful dose adjustments to avoid complications.
Possible mechanisms involved in the protective effect of lutein against cyclosporine-induced testicular damage in rats.
Heliyon
February 2024
Department of Human Physiology, Faculty of Basic Medical Science, Delta State University, Abraka, Delta State, Nigeria.
Oxidative stress and aberrant inflammatory response have important implications in cyclosporin-induced reproductive functions. Previous studies have shown that agents with antioxidant and anti-inflammatory activities might be beneficial in reversing cyclosporin-induced reproductive impairment. Lutein is a naturally occurring compound with antioxidant and anti-inflammatory properties.
View Article and Find Full Text PDFCyclosporine-induced erythromelalgia.
Pract Neurol
August 2023
Department of Neurology, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.
Erythromelalgia is a rare syndrome characterised by recurrent erythema, heat and burning pain in the extremities. There are two types: primary (genetic) and secondary (toxic, drug-related or associated with other diseases). We report a 42-year-old woman who developed erythromelalgia after taking cyclosporine for myasthenia gravis.
View Article and Find Full Text PDFCyclosporine-Induced Posterior Reversible Encephalopathy Syndrome: An Adverse Effect in a Patient With Atopic Dermatitis.
Cutis
March 2023
Dr. C.P. Dunn is from the Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle. Dr. C.L. Dunn is from the Department of Dermatology, KCU-GME/ADCS Consortium, Maitland, Florida. Dr. Petroni is from the Northwest Allergy and Asthma Center, University of Washington, Seattle.
Palliative Role of Zamzam Water against Cyclosporine-Induced Nephrotoxicity through Modulating Autophagy and Apoptosis Crosstalk.
Toxics
April 2023
Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
Cyclosporine (CsA) is considered one of the main components of treatment protocols for organ transplantation owing to its immunosuppressive effect. However, its use is very restricted due to its nephrotoxic effect. ZW is an alkaline fluid rich in various trace elements and has a great ability to stimulate antioxidant processes.
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