Aim: The aim of this study was to investigate the effect of 15 ml bupivacaine 0.25%, given via an epidural catheter, on the tissue-PO2 of the colon wall in humans.
Methods: Nine patients were studied during elective colorectal surgery. The tissue-PO2 was measured by polarography, using a multiwire surface probe.
Results: There was no significant change in cardiac index and arterial oxygen delivery after the injection of bupivacaine. At the serosal side of the colon wall the tissue-PO2 increased from 34 to 51 mmHg after epidural bupivacaine, which is statistically significant. Spinal nerve block produces sympathetic denervation of the bowel with an increase of regional nutritive blood flow.
Conclusion: It is concluded that epidural bupivacaine has a favourable effect on tissue oxygenation of the colon during colorectal surgery.
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