The mechanisms of DNA topoisomerases.

Trends Biochem Sci

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

Published: April 1995

Recent structural and mechanistic studies, as well as the discovery of new enzymes in the DNA topoisomerase family, allow these enzymes to be classified into three groups. Each group reflects the evolution of three different mechanistic strategies to manipulate DNA topology.

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http://dx.doi.org/10.1016/s0968-0004(00)88993-8DOI Listing

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