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Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues.
Chem Sci
January 2025
Université de Lorraine, CNRS, IMoPA F-54000 Nancy France
The polyketide specialized metabolites of bacteria are attractive targets for generating analogues, with the goal of improving their pharmaceutical properties. Here, we aimed to produce C-26 derivatives of the giant anti-cancer stambomycin macrolides using a mutasynthesis approach, as this position has been shown previously to directly impact bioactivity. For this, we leveraged the intrinsically broad specificity of the acyl transferase domain (AT) of the modular polyketide synthase (PKS), which is responsible for the alkyl branching functionality at this position.
View Article and Find Full Text PDFChange in self-determination-related constructs in persons with severe or profound intellectual and multiple disabilities in the context of transitions.
J Intellect Disabil
January 2025
Department of Clinical Child and Family Studies, Faculty of Behavioural and Movement Sciences and LEARN! Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
This study explored the changes in self-determination-related constructs during transitions in the lives of persons with severe or profound intellectual and multiple disabilities. Questionnaires about autonomy support, basic psychological need expressions, and subjective well-being were filled out twice by family caregivers who foresaw an important transition in the near future ( = 40; pre-post design). Average changes in outcomes across a period of 6-13 months were not statistically significant.
View Article and Find Full Text PDFUnexpected identification of peak systolic velocity in the radial artery as a risk factor for functional primary patency of radiocephalic fistulas.
Nefrologia (Engl Ed)
January 2025
Department of Ultrasound, The Second Hospital of Dalian Medical University, Dalian City, Liaoning Province, China. Electronic address:
Objective: As radiocephalic fistula is not necessarily appropriate for all patients with advanced kidney disease, our aim was to investigate the sensitive indicators that affect the functional primary patency of radiocephalic fistulas.
Methods: This prospective observational study included consecutive patients referred to the Second Hospital of Dalian Medical University for initial creation of radiocephalic fistula from July 2017 to December 2019. Preoperative ultrasound parameters, demographic characteristics, serum indicators and comorbidities were recorded.
Entity-enhanced BERT for medical specialty prediction based on clinical questionnaire data.
PLoS One
January 2025
School of Industrial and Management Engineering, Korea University, Seongbuk-gu, Seoul, Republic of Korea.
A medical specialty prediction system for remote diagnosis can reduce the unexpected costs incurred by first-visit patients who visit the wrong hospital department for their symptoms. To develop medical specialty prediction systems, several researchers have explored clinical predictive models using real medical text data. Medical text data include large amounts of information regarding patients, which increases the sequence length.
View Article and Find Full Text PDFRejection of the concept of hemiurid genus Pulmovermis (Digenea: Hemiuridae) and other taxonomic propositions: new morphological and molecular data regarding Lecithochirium cyanovitellosum (Coil and Kuntz, 1960) Urabe and Sokolov, comb. nov. (formerly Pulmovermis cyanovitellosus).
Syst Parasitol
January 2025
A.N. Severtsov Institute of Ecology and Evolution RAS, Moscow, Russia.
Pulmovermis cyanovitellosus Coil and Kuntz, 1960 is a species of hemiurid trematode that localizes in the lung of sea snakes, an unusual trait for this group of parasites. Recent molecular phylogenetic studies based on 28S rRNA gene sequences have shown that this species is closely related to members of the genus Lecithochirium Lühe, 1901. This finding is unexpected given that Pulmovermis Coil and Kuntz, 1960 and Lecithochirium are currently classified in different subfamilies of Hemiuridae (Pulmoverminae Sandars, 1961 vs.
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