This study demonstrates that peripheral apolipoprotein(a) [apo(a)] levels are higher in patients with polygenic hypercholesterolemia (PH) and combined hyperlipidemia (CH) than in controls. Levels of apo(a) inversely correlate with apo(a) isoform sizes. For a given apo(a) isoform, apo(a) levels are higher in PH and CH patients. Higher frequencies of smaller apo(a) isoforms were found in PH and CH patients than in controls, and in patients with coronary artery disease (CAD) or a family history of premature cardiovascular diseases than in patients without CAD or family history.
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