A method for comparing the fits of two non-nested models, based on a suggestion of Davidson and MacKinnon (1981), is developed in the context of linear and nonlinear regression with normal errors. Each model is regarded as a special case of an artificial "supermodel" and is obtained by restricting the value of a mixing parameter gamma to 0 or 1. To enable estimation and hypothesis testing for gamma, an approximate supermodel is used in which the fitted values from the individual models appear in place of the original parametrization. In the case of nested linear models, the proposed test essentially reproduces the standard F test. The calculations required are for the most part straight-forward (basically, linear regression through the origin). The test is extended to cover situations in which serious bias in the maximum likelihood estimate of gamma occurs, simple approximate bounds for the bias being given. Two real datasets are used illustratively throughout.
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BMC Bioinformatics
November 2024
Biomedical and Robotics Engineering, Incheon National University, 119 Academy-ro, Incheon, 22012, Yeonsu-gu, South Korea.
Background: RNA secondary structural alignment serves as a foundational procedure in identifying conserved structural motifs among RNA sequences, crucially advancing our understanding of novel RNAs via comparative genomic analysis. While various computational strategies for RNA structural alignment exist, they often come with high computational complexity. Specifically, when addressing a set of RNAs with unknown structures, the task of simultaneously predicting their consensus secondary structure and determining the optimal sequence alignment requires an overwhelming computational effort of for each RNA pair.
View Article and Find Full Text PDFPLoS One
September 2024
Edward S. Rogers, Sr. Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario, Canada.
Neighboring genes within a shared promoter arrangement (i.e. opposite direction with the neighboring ends as the transcriptional start sites) are expected to have a high similarity in genotype tissue expression due to the potential overlap in the promoter region.
View Article and Find Full Text PDFEduc Psychol Meas
April 2024
McGill University, Montreal, Quebec, Canada.
Item response theory (IRT) models are often compared with respect to predictive performance to determine the dimensionality of rating scale data. However, such model comparisons could be biased toward nested-dimensionality IRT models (e.g.
View Article and Find Full Text PDFBehav Res Methods
October 2024
Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195, Berlin, Germany.
Adv Radiat Oncol
May 2024
Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Purpose: To assess any correlation between swallowing dysfunction and radiation dose to 5 subregions of the larynx.
Methods And Materials: A cohort of 136 patients with head and neck cancer, treated with either photon or proton radiation therapy, was assessed using an endpoint of patient-reported swallowing scores, evaluated with the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire-H&N35 survey, within 1 month after treatment. Five subregions of the larynx were contoured, and dosimetric metrics were extracted for each subregion as well as the total larynx.
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