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CD3 antibody treatment stimulates the functional capability of regulatory T cells.
Novartis Found Symp
April 2004
Laboratoire d'Immunologie, Hôpital Necker, INSERM U580, 161 rae de Sivres, 75015 Paris, France.
Autoimmune diabetes progression in NOD mice is under the control of CD4+ regulatory T cells. In the thymus these regulatory cells are CD25+-like CD4+ cells shown to control physiologic organ-specific autoimmunity. In contrast, in the periphery, both CD4+CD25+ and CD4+CD25- cells exhibit regulatory capacities.
View Article and Find Full Text PDFObjective: The Medical Advisory Secretariat undertook a review of the evidence on the effectiveness and cost-effectiveness of small bowel transplant in the treatment of intestinal failure.
Small Bowel Transplantation: Intestinal failure is the loss of absorptive capacity of the small intestine that results in an inability to meet the nutrient and fluid requirements of the body via the enteral route. Patients with intestinal failure usually receive nutrients intravenously, a procedure known as parenteral nutrition.
FK506 conversion therapy in pediatric liver transplantation.
Transplantation
April 1994
Department of Transplantation, California Pacific Medical Center, San Francisco 94115.
The safety and efficacy of conversion to FK506 after failing immunosuppression with cyclosporine was prospectively evaluated in 31 pediatric liver transplant recipients between April 1991 and March 1993. The patients, who ranged in age from 40 days to 14 years, accounted for 28 primary transplantations and 3 retransplantations. The initial immunosuppression regimen consisted of cyclosporine in combination with prednisone.
View Article and Find Full Text PDFDifferential activation of p21ras in CD45RA+ and CD45RO+ human T lymphocytes.
J Immunol
March 1994
Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
CD45RA+ and CD45RO+ human T cells differ in their functional responses to different forms of mitogenic stimulation. However, little is known about the intracellular signaling events related to the functional differences in these two subsets. In the present study, we examined the ability of different Abs to the TCR/CD3 complex to activate the p21ras proto-oncogene product in CD45RA+ and CD45RO+ T cells.
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