AI Article Synopsis
- The study examined how different concentrations of natural and chemically modified cyclodextrins affect the luminescence of Escherichia coli, indicating a direct interaction between the cyclodextrins and the bacteria.
- Evidence showed that all cyclodextrins reduced luminescence, with varying levels of toxicity; gamma- and alpha-CD were the least toxic among natural cyclodextrins, while Dimeb was notably toxic among the modified forms.
- The toxicity ranking for natural cyclodextrins was beta-CD > alpha-CD > gamma-CD, and for chemically modified cyclodextrins was Dimeb > HPBCD > Trimeb > HPACD > HPGCD.
Article Abstract
The effect of various concentrations of natural and chemically modified cyclodextrins on the luminescence of an Escherichia coli suspension was investigated. All cyclodextrins were found to reduce, albeit to a varying degree, the luminescence level of the bacterial cells, thus suggesting a direct interaction between the cyclodextrins and cells. The inhibitory concentrations IC20 and IC50 of the various cyclodextrins were determined and taken to represent their toxicity effects upon the bacterial cells. Among the natural cyclodextrins, gamma- and alpha-CD interfered minimally with the bacterial luminescence and consequently were essentially non-toxic. The following descending order of toxicity was observed: beta-CD >> alpha-CD > gamma-CD. Among the chemically modified cyclodextrins, Dimeb was clearly toxic while Trimeb and the hydroxylated derivatives (hydroxypropyl-alpha-CD, HPACD; -beta-CD, HPBCD; -gamma-CD, HPGCD) were essentially non-toxic. The following descending order of toxicity was observed: Dimeb >> HPBCD > Trimeb > HPACD > HPGCD.
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| http://dx.doi.org/10.1007/BF00178492 | DOI Listing |
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