Many advances have been made in laboratory automation dealing with robotics and data management. There have been many different approaches to these technologies and many successful applications. Current methods employed in automated techniques utilize robotic processors and arms to manipulate and analyze samples, and computerized management of the data generated by these workhorses.
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Dynamic Force Sensing for Continuous Scraping Towards Endometrium Repair Surgery.
Int J Med Robot
February 2025
Shenyang Jianzhu University, Shenyang, China.
Background: A surgical robot with force feedback can guarantee precise and gentle manipulation for endometrial repair, ensuring the effectiveness and safety of the manipulation. However, the design of force sensors for surgical robots is challenging due to the limited anatomical space and the requirement for continuous rotation.
Methods: This paper presents a novel force-sensing surgical instrument for endometrial repair, including an inner scraping instrument and an outer force sensing sheath.
STEM education needs for human movement sciences professionals.
Front Neurol
January 2025
Department of Movement, Human, and Health Sciences, Laboratory of Exercise Physiology, University of Rome "Foro Italico", Rome, Italy.
Dimensional Regulation of Organic n-Type Dopants for Highly Efficient Perovskite Solar Cells and Modules.
Adv Mater
January 2025
College of Chemistry, Nanchang University, Nanchang, 330031, China.
A strong n-type perovskite layer is crucial in achieving high open-circuit voltage (V) and power conversion efficiency (PCE) in the p-i-n solar cells, as the weak n-type perovskites result in a loss of V, and the p-type perovskites contain numerous electron traps that cause the severe carrier recombination. Here, three types of perylene diimide (PDI) based small molecule dopants with different dimensions, including 1D-PDI, 2D-PDI, and 3D-PDI are designed, to produce heavier n-type perovskites. The PDI-based molecules with Selenium atoms have a strong electron-donating ability, effectively enlarging the quasi-Fermi level splitting within the perovskites.
View Article and Find Full Text PDFAtomic force microscopy combined with microfluidics for label-free sorting and automated nanomechanics of circulating tumor cells in liquid biopsy.
Nanoscale
January 2025
State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China.
Liquid biopsies are expected to advance cancer management, and particularly physical cues are gaining attention for indicating tumorigenesis and metastasis. Atomic force microscopy (AFM) has become a standard and important tool for detecting the mechanical properties of single living cells, but studies of developing AFM-based methods to efficiently measure the mechanical properties of circulating tumor cells (CTCs) in liquid biopsy for clinical utility are still scarce. Herein, we present a proof-of-concept study based on the complementary combination of AFM and microfluidics, which allows label-free sorting of individual CTCs and subsequent automated AFM measurements of the mechanical properties of CTCs.
View Article and Find Full Text PDFMechano-gated iontronic piezomemristor for temporal-tactile neuromorphic plasticity.
Nat Commun
January 2025
School of Future Technology, University of Chinese Academy of Sciences, 100190, Beijing, PR China.
In bioneuronal systems, the synergistic interaction between mechanosensitive piezo channels and neuronal synapses can convert and transmit pressure signals into complex temporal plastic pulses with excitatory and inhibitory features. However, existing artificial tactile neuromorphic systems struggle to replicate the elaborate temporal plasticity observed between excitatory and inhibitory features in biological systems, which is critical for the biomimetic processing and memorizing of tactile information. Here we demonstrate a mechano-gated iontronic piezomemristor with programmable temporal-tactile plasticity.
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