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Clinical improvements after endoscopic lung volume reduction with valves in patients with advanced emphysema and a 6-min walk test ≤140 m at baseline.
ERJ Open Res
January 2025
Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Background: Data regarding the effectiveness and safety of endoscopic lung volume reduction with valves (ELVR) in emphysema patients with a very low 6-min walk test (6MWT) are limited. Patients with severe emphysema and very low exercise capacity, as indicated by a 6MWT ≤140 m, are often excluded from clinical studies on ELVR, assuming limited therapeutic benefits and increased complication risk.
Study Designs And Methods: This study utilised data from the Lungenemphysemregister e.
Association between impaired diffusion capacity and small airway dysfunction: a cross-sectional study.
ERJ Open Res
January 2025
State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease & Guangzhou Institute of Respiratory Health & National Center for Respiratory Medicine & Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.
Background: Small airway dysfunction (SAD) and impaired diffusion capacity of the lungs for carbon monoxide ( ) are positively associated with a worse prognosis. Individuals with both dysfunctions have been identified in clinical practice and it is unknown whether they have worse health status or need management. We conducted this study to explore the association between SAD and impaired , and the difference between the groups with two dysfunctions, with either one dysfunction and with no dysfunction.
View Article and Find Full Text PDFDesign and implementation of optics for the experiment for cryogenic large-aperture intensity mapping (EXCLAIM).
Rev Sci Instrum
January 2025
NASA Goddard Space Flight Center, Greenbelt, Maryland 20771, USA.
This work describes the design and implementation of optics for EXCLAIM, the EXperiment for Cryogenic Large-Aperture Intensity Mapping. EXCLAIM is a balloon-borne telescope that will measure integrated line emission from carbon monoxide at redshifts z < 1 and ionized carbon ([CII]) at redshifts z = 2.5 - 3.
View Article and Find Full Text PDFOptimizing Exposure Measures in Large-Scale Household Air Pollution Studies: Results from the Multicountry HAPIN Trial.
Environ Sci Technol
January 2025
Rollins School of Public Health, Emory U, Atlanta, Ga 30322, United States.
Repeated measurements of household air pollution may provide better estimates of average exposure but can add to costs and participant burden. In a randomized trial of gas versus biomass cookstoves in four countries, we took supplemental personal 24-h measurements on a 10% subsample for mothers and infants, interspersed between protocol samples. Mothers had up to five postrandomization protocol measurements over 16 months, while infants had three measurements over one year.
View Article and Find Full Text PDFPredicting delayed neurological sequelae in patients with carbon monoxide poisoning using machine learning models.
Clin Toxicol (Phila)
January 2025
Department of Emergency Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Introduction: Delayed neurological sequelae is a common complication following carbon monoxide poisoning, which significantly affects the quality of life of patients with the condition. We aimed to develop a machine learning-based prediction model to predict the frequency of delayed neurological sequelae in patients with carbon monoxide poisoning.
Methods: A single-center retrospective analysis was conducted in an emergency department from January 01, 2018, to December 31, 2023.
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