The changes occurring in the proliferation and differentiation of pluripotent hematopoietic stem cells under the action of different doses of benzylpenicillin and aspisole were investigated by using models of sublethally and lethally irradiated mice. The mitogenic and mitostatic dose-dependent effects of the drugs were revealed at the very early stages of immunogenesis and hemopoiesis. These effects show themselves in different ways (depending on the predominance of T- and B-lymphocytic conditions for T-B-cooperation and so on.
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