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Unraveling the role of GOLM1-OPN-ABCG5 axis in MASH: Editorial on "GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in MASH livers".
Clin Mol Hepatol
January 2025
Department of Biochemistry, College of Natural Sciences, Kangwon National University, 24341 Chuncheon, Republic of Korea.
Oxidative balance scores and gallstone disease: mediating effects of oxidative stress.
Nutr J
January 2025
The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Background: Gallstone disease (GSD) is a prevalent gastrointestinal disorder, few studies have examined the combined effects of dietary and lifestyle factors on GSD. This study aims to investigate the relationship between oxidative balance score (OBS) and GSD, and explores the potential mediating role of oxidative stress.
Methods: Cross-sectional data from 6,196 participants in the NHANES 2017-2020 were analyzed.
How do inflammatory marker dynamics shift with acute calculous cholecystitis severity?
Ulus Travma Acil Cerrahi Derg
January 2025
Department of General Surgery, Istanbul Training and Research Hospital, Istanbul-Türkiye.
Introduction: Gallstone may cause complications of cholecystitis, gallbladder gangrene, perforation, and related sepsis. This study aims to identify how CRP and immune cells change in patients with acute calculous cholecystitis based on the severity of disease.
Method: Patients with acute calculous cholecystitis were categorized into three main groups-mild, moderate, and severe-based on the Tokyo guidelines.
Association between metabolic dysfunction associated steatotic liver disease and gallstones in the US population using propensity score matching.
Sci Rep
January 2025
Department of General Surgery, The Affiliated Wuxi Fifth Hospital of Jiangnan University, No. 1215 Guangrui Road, Wuxi, 214005, Jiangsu, China.
The novel diagnostic term Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) requires at least one cardiovascular risk factor for diagnosis. While the relationship between gallstones and Non-Alcoholic Fatty Liver Disease (NAFLD) has been debated, the association between MASLD and gallstones remains unclear. This cross-sectional study aimed to explore this relationship using National Health and Nutrition Examination Survey (NHANES) data from 2017 to 2020.
View Article and Find Full Text PDFAssociations of phthalate and phthalate alternative metabolites in urine with the risk of gallstones in adults: a cross-sectional analysis.
Environ Geochem Health
January 2025
Institute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou, 730000, Gansu, China.
Article Synopsis
- The study investigates whether phthalates and their alternatives are linked to the occurrence of gallstones, involving 1,735 NHANES participants.
- Individual associations of specific phthalate metabolites (MCOCHP and MHNCH) were found to have a positive correlation with gallstones, particularly in older adults, men, and those with certain health conditions.
- Findings indicate that both traditional phthalates and their alternatives elevate the risk of gallstones, with alternatives posing a greater risk, especially among vulnerable populations like the elderly and those with obesity, hypertension, or diabetes.
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