Pulmonary metastases from a uterine choriocarcinoma are rare in France. The authors report a case of a 42 years old patient who presented more than four years after her last pregnancy with a metastasis in the left lower lobe due to a uterine choriocarcinoma. There was a favourable outcome after combined treatment with chemotherapy and surgery. The patient had been in hospital eighteen months earlier for a spontaneous left haemothorax secondary to a ruptured intrapleural pulmonary arterio-venous aneurysm (AVV) of the left lower lobe which was treated by embolisation. The aetiology of pulmonary AVV are defined, and the pathophysiology of uterine carcinoma as well as the probable association and pulmonary vascular anomalies are discussed.
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Int J Pharm
January 2025
The Key Laboratory of Biomedical Material, School of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003 China. Electronic address:
This study focuses on the preparation and characterization of platelet membrane biomimetic nanocarriers (P-PLGA NPs) and investigates their interactions with the transplacental barrier. Poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) were coated with platelet membrane (PLTM) to construct P-PLGA NPs. Additionally, fluorinated polyethylenimine (F-PEI) was grafted onto PLGA NPs to prepare F-PEI-PLGA NPs, which were compared with PLGA NPs.
View Article and Find Full Text PDFJ Obstet Gynaecol Res
January 2025
Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo University, Bunkyō, Japan.
We report a case of placental site trophoblastic tumor (PSTT) with transient hyperthyroidism. A 29-year-old gravida 2 para 2 woman presented with abnormal genital bleeding 6 months after delivery. Endometrial histology suggested PSTT.
View Article and Find Full Text PDFEur J Obstet Gynecol Reprod Biol
February 2025
Sheffield Trophoblastic Disease Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Introduction: Gestational trophoblastic neoplasia (GTN) is rare in the UK, with an estimated incidence of one in 50,000 live births. Cases of vaginal metastasis are even rarer, with only eight case series reporting 187 cases over the past 40 years. Management recommendations in the literature are scarce despite the potential risk of massive, potentially life-threatening vaginal haemorrhage.
View Article and Find Full Text PDFFront Oncol
November 2024
Department of Gynecology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China.
BMJ Case Rep
November 2024
Shalinitai Meghe Hospital and Research Centre, Wanadongri, Nagpur, India.
Gestational trophoblastic disease is a group of pregnancy-related trophoblastic tumours. Gestational trophoblastic neoplasia refers to its invasive and malignant forms: invasive mole, choriocarcinoma, placental site trophoblastic tumour and epithelioid trophoblastic tumour. Patients exhibit elevated beta human chorionic gonadotropin (β hCG) levels, sometimes exceeding 100 000 mIU/mL.
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