There is no current international consensus on the classification of microcarcinomas. There is still controversy over the depth of the stroma invasion and lymph node invasion as well as on confluence of invasive spread. The FIGO classification has been used since 1985 in which microinvasive carcinomas are considered as infraclinical cancers forming a group classed as stage 1a and divided into subgroups: 1a1 = early invasion of the stroma < 1 mm in depth; 1a2 = microinvasive carcinoma with invasion < 5 mm and width < 7 mm. Two important practical points must be added to this classification: demonstration of emboli via lymphatic or blood stream dissemination. Microinvasive carcinoma is demonstrated on conization specimens obtained after guided biopsy revealed intraepithelial neoplasia. Treatment can be standardized on the basis of the pathology report on the conization specimen.
Download full-text PDF |
Source |
---|
J Taibah Univ Med Sci
February 2025
Shahid Beheshti University of Medical Sciences, Faculty of Dentistry, Department of Oral & Maxillofacial Pathology, Tehran, Iran.
Objective: This study was aimed at investigating the roles of podoplanin (PDPN) as a marker associated with malignant development, progression, and poor prognosis in oral leukoplakia and various forms of oral squamous cell carcinoma (OSCC), particularly in relation to the extent of invasion.
Methods: Immunohistochemical analysis of PDPN was conducted on 77 histologically confirmed, formalin-fixed, paraffin-embedded samples representing various degrees of OSCC invasion and dysplasia grades.
Results: The samples were analyzed with Fisher's exact test and the Kruskal-Wallis test.
Natl J Maxillofac Surg
November 2024
Department of Oral and Maxillofacial Surgery, King George's Medical University, Lucknow, Uttar Pradesh, India.
Microinvasive oral squamous cell carcinoma (MISCC) is the early stage of oral cancer that shows a breach in the basement membrane, and the depth of invasion of the tumour is limited to 0.5-2mm into the papillary stroma. A review of the available data on MISCC was conducted to formulate a management protocol for MISCC and to assess the association of MISCC with oral potentially malignant disorders.
View Article and Find Full Text PDFSci Rep
January 2025
Cawley Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute Christiana Care Health Services, Inc., 4701 Ogletown Stanton Rd Suite 4300, Newark, DE, 19713, USA.
Triple-negative breast cancer (TNBC) is an aggressive subtype often characterized by high lymphocyte infiltration, including tumor-infiltrating B cells (TIBs). These cells are present even in early stages of TNBC and associated with microinvasion. This study shows that co-culturing TNBC cells with B cells increases Interleukin-1β (IL-1β) expression and secretion.
View Article and Find Full Text PDFRes Sq
December 2024
Helen F Graham Cancer Center, and Research Institute.
Triple-negative breast cancer (TNBC) is an aggressive subtype often characterized by high lymphocyte infiltration, including tumor-infiltrating B cells (TIBs). These cells are present even in early stages of TNBC and associated with microinvasion. This study shows that co-culturing TNBC cells with B cells increases Interleukin-1β (IL-1β) expression and secretion.
View Article and Find Full Text PDFInt J Surg Pathol
January 2025
Department of Pathology and Laboratory Medicine, Mayo Clinic, Jacksonville, FL, USA.
. To identify the most common reasons for consultation to a large specialty breast pathology service at a major institution. To provide insight into the overall challenges in practicing breast pathology.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!