AI Article Synopsis
- A rise in post-synaptic calcium concentration is crucial for the induction of long-term potentiation (LTP) in neurons.
- The study investigates the role of voltage-gated calcium channels (VGCC) in AP5-sensitive LTP induced by theta-burst stimulation in guinea-pig hippocampal CA1 neurons.
- Using VGCC blockers, the experiment shows that blocking these channels significantly reduces the amount of induced LTP, highlighting their importance in the process.
Article Abstract
It is widely believed that a rise in post-synaptic calcium concentration ([Ca2+]i) is a necessary step in the induction of long-term potentiation (LTP) (Bliss and Collingridge, Nature, 361 (1993) 31-39). In this experiment, we examine the involvement of voltage-gated Ca2+ channels (VGCC) in the induction of AP5-sensitive LTP induced by theta-burst stimulation in guinea-pig hippocampal CA1 neurons. The VGCC blockers, Ni2+ (25 microM, T-channel blocker) or omega-AgaIVA (60 nM, P-channel blocker), which have no effect on synaptic transmission, suppress 60% or 78% of the theta-burst induced LTP, respectively. This implies that Ca2+ entry through VGCC is an important step in this form of LTP.
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| http://dx.doi.org/10.1016/0304-3940(94)11127-5 | DOI Listing |
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