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An autonomous navigation method for orchard mobile robots based on octree 3D point cloud optimization.
Front Plant Sci
January 2025
Institute of Agricultural Facilities and Equipment, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China.
Three-dimensional (3D) LiDAR is crucial for the autonomous navigation of orchard mobile robots, offering comprehensive and accurate environmental perception. However, the increased richness of information provided by 3D LiDAR also leads to a higher computational burden for point cloud data processing, posing challenges to real-time navigation. To address these issues, this paper proposes a 3D point cloud optimization method based on the octree data structure for autonomous navigation of orchard mobile robots.
View Article and Find Full Text PDFIdentification of ALEKSIN as a novel multi-IRF inhibitor of IRF- and STAT-mediated transcription in vascular inflammation and atherosclerosis.
Front Pharmacol
January 2025
Human Molecular Genetics Research Unit, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland.
Cardiovascular diseases (CVDs) include atherosclerosis, which is an inflammatory disease of large and medium vessels that leads to atherosclerotic plaque formation. The key factors contributing to the onset and progression of atherosclerosis include the pro-inflammatory cytokines interferon (IFN)α and IFNγ and the pattern recognition receptor (PRR) Toll-like receptor 4 (TLR4). Together, they trigger the activation of IFN regulatory factors (IRFs) and signal transducer and activator of transcription (STAT)s.
View Article and Find Full Text PDFArtificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from L.- Hand.-Mazz. herb pair.
Front Pharmacol
January 2025
School of Pharmacy, Jiangsu University, Zhenjiang, China.
Introduction: The L. (PVL) and Hand.-Mazz.
View Article and Find Full Text PDFApigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages independently of CD38.
Front Immunol
January 2025
Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway.
Introduction: CD38, a regulator of intracellular calcium signalling, is highly expressed in immune cells. Mice lacking CD38 are very susceptible to acute bacterial infections, implicating CD38 in innate immune responses. The effects of CD38 inhibition on NLRP3 inflammasome activation in human primary monocytes and monocyte-derived macrophages have not been investigated.
View Article and Find Full Text PDFMagnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels.
Front Immunol
January 2025
Adaptive Biotechnologies, Seattle, WA, United States.
Introduction: T cells are involved in the early identification and clearance of viral infections and also support the development of antibodies by B cells. This central role for T cells makes them a desirable target for assessing the immune response to SARS-CoV-2 infection.
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