AI Article Synopsis
- Researchers identified the MN1 gene on chromosome 22, which is disrupted by a balanced translocation (4;22) in a type of brain tumor called meningioma 32.
- The MN1 gene consists of approximately 70 kb with two large exons and encodes a protein made of 1,319 amino acids, featuring two CAG repeat sequences.
- In meningioma 32, there is no detected expression of the MN1 mRNA, indicating that the inactivation of this gene may play a role in the tumor's development.
Article Abstract
We have isolated a gene, called MN1, which resides on chromosome 22 and which was found to be disrupted by a balanced translocation (4;22) in meningioma 32. The MN1 gene spans about 70 kb and consists of at least two large exons of approximately 4.7 kb and 2.8 kb. The MN1 cDNA codes for a protein of 1319 amino acids when the first methionine in the open reading frame is used. The MN1 cDNA contains two CAG repeats, one of which codes for a string of 28 glutamines. The t(4;22) disrupts the 5'-exon within the open reading frame. In meningioma 32 no expression of the MN1 mRNA is observed. These results suggest that inactivation of the MN1 gene in this tumour may contribute to its pathogenesis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
RNAseq of peripheral blood mononucleated cells exposed to platelet-rich fibrin and enamel matrix derivatives.
Sci Rep
January 2025
Department of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, Sensengasse 2a, 1090, Vienna, Austria.
Platelet-rich fibrin (PRF) and Enamel Matrix Derivatives (EMD) can support the local regenerative events in periodontal defects. There is reason to suggest that PRF and EMD exert part of their activity by targeting the blood-derived cells accumulating in the early wound healing blastema. However, the impact of PRF and EMD on blood cell response remains to be discovered.
View Article and Find Full Text PDFMicroRNAs Expression Profile in MN1-Altered Astroblastoma.
Biomedicines
January 2025
Department of Radiological, Oncological and Anatomo-Pathological Sciences, University Sapienza of Rome, 00161 Rome, Italy.
Background/objectives: Astroblastoma is a rare glial neoplasm more frequent in young female patients, with unclear clinical behaviors and outcomes. The diagnostic molecular alteration is a rearrangement of the Meningioma 1 () gene. MicroRNAs (miRNAs) are important gene expression regulators with strong implications in biological processes.
View Article and Find Full Text PDFPediatric Mesenchymal Tumor With MN1::TAF3 Fusion.
Genes Chromosomes Cancer
November 2024
Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.
MN1 fusion is emerging as oncogenic in soft-tissue tumors. Here, we provided detailed clinicopathological documentation of a tumor with MN1::TAF3 fusion. The tumor developed on the face of an 8-year-old boy and did not recur or metastasize for 5 years after surgery without adjuvant therapy.
View Article and Find Full Text PDFMolecular characterization of Staphylococcus aureus from nasal samples of healthy pet cats.
Lett Appl Microbiol
November 2024
Hospices Civils de Lyon, Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, LyonF-69004, France.
The objective of this study was to characterize Staphylococcus aureus isolates recovered from the nasal samples of healthy pet cats in Algiers province. A total of 138 nasal swabs were collected. Antimicrobial susceptibility was conducted using the disk-diffusion method and the VITEK-2 susceptibility system.
View Article and Find Full Text PDFAstroblastoma: A molecularly defined entity, its clinico-radiological & pathological analysis of eight cases and review of literature.
Pathol Res Pract
November 2024
Neuropathology Laboratory, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi, India. Electronic address:
Astroblastoma, a unique entity of glial tumor, predominantly occur in young women with distinctive MN1 rearrangement, Given its limited documentation in existing literature, we report eight cases of astroblastoma, detailing their clinical, radiological, and histopathological characteristics along with molecular analysis. We conducted a retrospective analysis of our neuropathology archive database spanning the past 8 years. We included all cases that underwent Magnetic Resonance Imaging (MRI), surgical resection, histopathological examination, molecular testing, and follow-up.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!