The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there is uncertainty about the strength of association and the role of co-factors is unclear. This population-based case-control study in Norwegian women 20-44 years of age included 103 cases with histologically confirmed CIN II-III and 234 age-matched and randomly selected controls. Cytological specimens from the cervix were analyzed using the polymerase chain reaction (PCR). In all, 91% of the cases and 15% of the controls were HPV DNA positive, giving a crude odds ratio (OR) of 67.2 (95% confidence interval: 28.6-157.5). The association between HPV 16 and CIN II-III was even stronger (crude OR = 123.9; 46.7 - 328.5). In logistic regression analysis, additional to HPV, only a high number of sexual partners and a low educational level contributed independently to the risk. The adjusted OR for the association between HPV and CIN II-III was 72.8 (95% CI: 27.6-191.9). The association between HPV and CIN remains very strong even after adjustment for proposed confounding factors. The results therefore support the role of HPV as a causative agent in the development of CIN.
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[Obstetric-gynecological and social factors for the development of cervical intraepithelial neoplasia].
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Instituto Mexicano del Seguro Social, Unidad de Medicina Familiar No. 15, Coordinación Clínica de Educación e Investigación en Salud. Ciudad de México, México.
Background: Cervical intraepithelial neoplasia (CIN) precedes cervical cancer and it is associated with risk factors that can be identified in the population, which contribute to timely diagnosis and treatment.
Objective: To identify associated risk factors for the development of CIN in women attended at the first level of care.
Material And Methods: A cross-sectional and retrospective study was conducted in women in the 2020-2022 period.
[Obstetric-gynecological and social factors for the development of cervical intraepithelial neoplasia].
Rev Med Inst Mex Seguro Soc
September 2024
Instituto Mexicano del Seguro Social, Unidad de Medicina Familiar No. 15, Coordinación Clínica de Educación e Investigación en Salud. Ciudad de México, México.
Background: Cervical intraepithelial neoplasia (CIN) precedes cervical cancer and it is associated with risk factors that can be identified in the population, which contribute to timely diagnosis and treatment.
Objective: To identify associated risk factors for the development of CIN in women attended at the first level of care.
Material And Methods: A cross-sectional and retrospective study was conducted in women in the 2020-2022 period.
Demographic, Social, Behavioral, and Clinical Characteristics Associated with Long-Term Opioid Therapy and Any Opioid Prescription in High-Risk VA Patients.
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Unit of Obstetrics and Gynaecology, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, I-42122 Reggio Emilia, Italy.
While cervical cancer is relatively uncommon in Western countries, it continues to pose significant concern due to its high mortality rates. Intraepithelial forms [cervical intraepithelial neoplasia (CIN) 2 and CIN 3] are more prevalent in regions with comprehensive screening coverage, particularly in areas that use the Papanicolaou test and HPV detection. The present study aims to characterize the trends of precancerous lesions and infiltrating tumors over a decade, assessing survival rates by age, stage and country of origin.
View Article and Find Full Text PDFThe expression analysis of human endogenous retrovirus-K Env, Np9, and Rec transcripts in cervical cancer.
J Med Virol
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Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
While infection with high-risk human papillomavirus (HPV) types is necessary for cervical cancer (CC) development, it is not enough, and other risk factors are required. Several studies have reported the activation of HERV-K in different cancers; however, the investigation of HERV-K expression levels in CC is scarce. In this study, it was hypothesized that activation of HERV-K could play an essential role in CC development.
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