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Understanding the medication regimens associated with anticholinergic burden in older people's mental health services in the UK.
BJPsych Open
October 2024
Division of Psychiatry, Imperial College London, London, UK.
Background: Medications with anticholinergic properties are associated with a range of adverse effects that tend to be worse in older people.
Aims: To investigate medication regimens with high anticholinergic burden, prescribed for older adults under the care of mental health services.
Method: Clinical audit of prescribing practice, using a standardised data collection tool.
Factors associated with lamotrigine concentration/dose ratio in individuals with bipolar disorders.
Eur Neuropsychopharmacol
August 2023
Université Paris Cité Inserm UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, 75006, Paris, France; Fondation FondaMental, 94010, Créteil, France; Centres Experts Trouble Bipolaire et Dépression Résistante, Assistance Publique des Hôpitaux de Paris, Hôpital Lariboisière-Fernand Widal, 75010 Paris, France.
Monitoring of lamotrigine levels is recommended in epilepsy. However, in bipolar disorders (BD), no study has described the therapeutic range in daily practice and factors being associated to it. We used retrospective data of individuals with BD, treated with lamotrigine, and included in the FondaMental Advanced Centers of Expertise for Bipolar Disorders cohort.
View Article and Find Full Text PDFDose-dependent effect of lamotrigine on quetiapine serum concentration in patients using instant release tablets.
Eur J Clin Pharmacol
June 2024
Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.
Purpose: Lamotrigine was previously reported to reduce serum concentration of quetiapine. The aim of this study was to investigate whether lamotrigine dose or quetiapine formulation was of importance for the drug interaction.
Methods: Patients combining lamotrigine with quetiapine (cases) were included retrospectively from a routine therapeutic drug monitoring (TDM) service, as were a control group of patients using quetiapine without any interacting drugs.
Optimizing antidepressant and clozapine co-prescription in clinical practice: A systematic review and expert recommendations.
Schizophr Res
June 2024
Mental Health Research Center at Eastern State Hospital, Lexington, KY, Psychiatry and Neurosciences Research Group (CTS-549), USA; Institute of Neurosciences, University of Granada, Granada, Spain; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain.
Objectives: To synthesize the information relevant for clinical practice on clozapine-antidepressant co-prescription concerning pharmacokinetic drug-drug interactions (DDI), adverse drug reactions (ADRs) associated with the co-prescription, antidepressant add-on for clozapine-resistant symptoms and antidepressant add-on for clozapine-induced ADRs.
Methods: Articles were identified with MEDLINE, Web of Sciences and PsycINFO search from inception through April 2023. Data were synthesized narratively.
Non-fatal overdose risk associated with prescribing opioid agonists concurrently with other medication: Cohort study conducted using linked primary care, secondary care and mortality records.
Addiction
December 2023
National Institute for Health and Care Research Greater Manchester Patient Safety Translational Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Background And Aims: An apparently protective effect of opioid agonist treatment (OAT) on all-cause and cause-specific mortality risk has been widely reported. Non-fatal overdose (NFO) often precedes subsequent drug-poisoning deaths. We hypothesized that benzodiazepines, gabapentinoids, antipsychotics, antidepressants, Z-drugs or opioids increase the NFO risk when co-prescribed with OAT.
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