A-ring annulated heterocycles, the isoxazole 6, the pyrazoles 8 and the pyrimidines 9 are prepared starting from 2-hydroxymethylene canrenone 1. Binding studies were carried out with the compounds 1 and 6-8 using estrogen, progesterone, androgen, gluco- and mineralocorticoid receptors as well as the serum proteins SHBG and CBG: the substances were inactive on the receptor level. 1, 7 and 8a show weak binding affinity to CBG.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ardp.19953280212 | DOI Listing |
Publication Analysis
Top Keywords
[heterocyclic annulated
4
annulated steroids
4
steroids 2-hydroxymethylene-canrenone]
4
2-hydroxymethylene-canrenone] a-ring
4
a-ring annulated
4
annulated heterocycles
4
heterocycles isoxazole
4
isoxazole pyrazoles
4
pyrazoles pyrimidines
4
pyrimidines prepared
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!