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Single and combined effect of chrysin and N-acetylcysteine against deltamethrin exposure in rats.

Food Chem Toxicol

December 2024

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Turkey. Electronic address:

Effects of chrysin and N-acetylcysteine on deltamethrin exposure in rats were investigated. Eighty male Wistar Albino rats, weighing between 150 and 200 g and aged 2-3 months, were used and evenly allocated into eight groups. The control group of rats received a corn oil vehicle.

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Article Synopsis
  • Nephrolithiasis, a common kidney condition that can lead to kidney failure, is influenced by oxidative stress, prompting research into agents that may alleviate this issue, such as MC extract, known for its antioxidant properties.* -
  • The study involved Wistar albino rats divided into four groups, where nephrolithiasis was induced using ethylene glycol, and the effects of preventive and therapeutic MC extract were evaluated through urine and tissue analysis.* -
  • Results showed that MC extract successfully normalized urine and tissue parameters associated with oxidative stress and tissue damage, indicating potential for clinical use in preventing kidney stone formation through further research.*
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The manifestations of tuberous sclerosis complex (TSC) in humans include epilepsy, autism spectrum disorders (ASD) and intellectual disability. Previous studies suggested the linkage of TSC to altered cerebral blood flow and metabolic dysfunction. We previously reported a significant elevation in cerebral blood flow in an animal model of TSC and autism of young Eker rats.

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Objective: Nephrolithiasis is a common cause of kidney insufficiency. Nephrolithiasis is proven to be the result of various biochemical and inflammatory processes that result in crystal formation and subsequent aggregation. Cotinuscoggygria L.

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Biomolecules to Biomarkers? U87MG Marker Evaluation on the Path towards Glioblastoma Multiforme Pathogenesis.

Pharmaceutics

January 2024

Department of Medical Genetics, Third Faculty of Medicine, Charles University, Ruská 87, Vinohrady, 10000 Prague, Czech Republic.

The heterogeneity of the glioma subtype glioblastoma multiforme (GBM) challenges effective neuropathological treatment. The reliance on in vitro studies and xenografted animal models to simulate human GBM has proven ineffective. Currently, a dearth of knowledge exists regarding the applicability of cell line biomolecules to the realm of GBM pathogenesis.

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