Objective: To achieve fertilization and cleavage by spermatozoa retrieved by testicular biopsy from a male with testicular tubular atrophy.
Design: Clinical trial.
Setting: Private reproductive institute.
Patient: Azoospermic male with demonstrated testicular tubular atrophy and almost complete spermatogenic arrest.
Intervention: Open biopsy retrieval of testicular tissue and sperm followed by intracytoplasmic sperm injection.
Main Outcome Measures: Fertilization and cleavage.
Results: One four- to six-cell embryo was formed after intracytoplasmic sperm injection of five eggs with extruded polar bodies by retrieved sperm.
Conclusion: Intracytoplasmic sperm injection after testicular sperm aspiration may be attempted in cases with severely decreased spermatogenesis and result in fertilization, cleavage, and embryo transfer.
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