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Large soluble CD18 complexes with exclusive ICAM-1-binding properties are shed during immune cell migration in inflammation.
J Transl Autoimmun
June 2025
Department of Biomedicine, Aarhus University, Denmark.
The family of heterodimeric CD11/CD18 integrins facilitate leukocyte adhesion and migration in a wide range of normal physiologic responses, as well as in the pathology of inflammatory diseases. Soluble CD18 (sCD18) is found mainly in complexes with hydrodynamic radii of 5 and 7.2 nm, suggesting a compositional difference.
View Article and Find Full Text PDFEndothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis.
Ren Fail
December 2025
Department of Nephrology, Chengyang District People's Hospital, Qingdao, China.
Background: Vascular calcification is common and progressive in patients with chronic kidney disease. However, the risk factors associated with the progression of vascular calcification in patients receiving maintenance dialysis have not been fully elucidated. Here, we aimed to evaluate vascular calcification and identify the factors associated with its progression in patients receiving maintenance hemodialysis.
View Article and Find Full Text PDFA Primer on Proteomic Characterization of Intercellular Communication in a Virus Microenvironment.
Mol Cell Proteomics
January 2025
Department of Molecular Biology, Princeton University; Princeton, NJ USA 08544. Electronic address:
Intercellular communication is fundamental to multicellular life and a core determinant of outcomes during viral infection, where the common goals of virus and host for persistence and replication are generally at odds. Hosts rely on encoded innate and adaptive immune responses to detect and clear viral pathogens, while viruses can exploit or disrupt these pathways and other intercellular communication processes to enhance their spread and promote pathogenesis. While virus-induced signaling can result in systemic changes to the host, striking alterations are observed within the cellular microenvironment directly surrounding a site of infection, termed the virus microenvironment (VME).
View Article and Find Full Text PDFPhosphorus-solubilizing fungi promote the growth of P. Y. Li by regulating physiological and biochemical reactions and protecting enzyme system-related gene expression.
Front Genet
January 2025
Chongqing Engineering Laboratory of Green Planting and Deep Processing of Famous-Region Drug in the Three Gorges Reservoir Region, College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, China.
Introduction: P. Y. Li is a plant used to treat respiratory diseases such as pneumonia, bronchitis, and influenza.
View Article and Find Full Text PDFCorrelation between preoperative aqueous cytokine levels and mid-term corneal endothelial cell loss following penetrating keratoplasty.
Eye (Lond)
January 2025
Department of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan.
Objective: To investigate the association between preoperative aqueous humour (AqH) cytokines and mid-term endothelial cell density (ECD) following penetrating keratoplasty (PKP).
Methods: This study analysed a total of 87 eyes of which 54 underwent PKP and 33 eyes underwent cataract surgery. AqH samples were collected at the beginning of surgery.
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