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Engineered Strategies for Lipid Droplets-Targeted AIEgens Based on Tetraphenylethene.
Molecules
December 2024
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen 518172, China.
Lipid droplets (LDs), once regarded as inert fat particles, have been ignored by scientific researchers for a long time. Now, studies have shown that LDs are dynamic organelles used to store neutral lipids in cells and maintain cell stability. The abnormality of intracellular LDs usually causes metabolic disorders in the body, such as obesity, atherosclerosis, diabetes, and cancer, so the LDs have attracted wide attention.
View Article and Find Full Text PDFA novel BLK heterozygous mutation (p.Met121lle) in maturity-onset diabetes mellitus: A case report and literature review.
Diabet Med
January 2025
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Department of Endocrinology, Geriatric Medicine Center, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.
Maturity onset diabetes of the young (MODY) is a highly heterogeneous monogenic disease that occurs due to β-cell dysfunction. It is divided into different types depending on the gene mutated, and a total of 16 genes have been found to be associated with MODY. However, due to the current lack of understanding of monogenic diabetes, 90% of MODY is currently misdiagnosed and ignored in clinical practice.
View Article and Find Full Text PDFIntegration of Optical Coherence Tomography Images and Real-Life Clinical Data for Deep Learning Modeling: A Unified Approach in Prognostication of Diabetic Macular Edema.
J Biophotonics
December 2024
Medical Faculty, Ophthalmology Department, University of Health Sciences, Istanbul, Türkiye.
The primary ocular effect of diabetes is diabetic retinopathy (DR), which is associated with diabetic microangiopathy. Diabetic macular edema (DME) can cause vision loss for people with DR. For this reason, deciding on the appropriate treatment and follow-up has a critical role in terms of curing the disease.
View Article and Find Full Text PDFA reinforcement learning approach to effective forecasting of pediatric hypoglycemia in diabetes I patients using an extended de Bruijn graph.
Sci Rep
December 2024
Computer Science Department, Indiana University, Bloomington, IN, USA.
Pediatric diabetes I is an endemic and an especially difficult disease; indeed, at this point, there does not exist a cure, but only careful management that relies on anticipating hypoglycemia. The changing physiology of children producing unique blood glucose signatures, coupled with inconsistent activities, e.g.
View Article and Find Full Text PDFEstimating the prevalence of diabetic retinopathy in electronic health records with massive missing labels.
Intell Based Med
July 2024
School of Industrial Engineering and Management, Oklahoma State University, Stillwater, OK, USA.
Objective: The paper aims to address the problem of massive unlabeled patients in electronic health records (EHR) who potentially have undiagnosed diabetic retinopathy (DR). It is desired to estimate the actual DR prevalence in EHR with 96 % missing labels.
Materials And Methods: The Cerner Health Facts data are used in the study, with 3749 labeled DR patients and 97,876 unlabeled diabetic patients.
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