It is demonstrated that the abundance of bactericidal compounds in the salivary cement plug of ixodid ticks is changing under the influence of virulent tick-borne encephalitis virus (TBEV) reproduction in their bodies. TBEV infected Ixodes persulcatus cement plug-forming lytic zone size enlarged in comparison with the naive tick one whereas Micrococcus lysodeikticus lytic zones induced by the cement plug of TBEV infected Amblyomma hebraeum nymphs or Rhipicephalus appendiculatus females reduced compared with produced by noninfected specimens. It is supposed that increasing of the lysozyme that production by the main TBEV vectors (Ixodinae ticks) infected salivary gland cells in comparison with suppression of the bactericidal qualities of saliva of the ticks which are not TBEV vectors in the nature (Amblyomminae ticks) is one of markers of the specificity of I. persulcatus-TBE virus interface.
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