Purpose: We propose a noninvasive method for the measurement of orocecal transit time assessed by the sulfapyridine appearance time in saliva after ingestion of sulfasalazine.
Method: In 12 healthy volunteers, we studied the correlation between plasma and saliva sulfapyridine appearance times and then the sulfapyridine appearance times in saliva under various experimental conditions to assess the reproducibility, the effects of meals, and the role of the formulation, and the effects of gastrointestinal kinetic drugs.
Results: The correlation between saliva and plasma sulfapyridine appearance times was strong (r = 0.84; p = 0.0004). The sulfapyridine saliva appearance time was significantly delayed by the meal. Compared with placebo, the saliva sulfapyridine appearance time was reduced by cisapride (312 +/- 128 versus 551 +/- 97 minutes; p = 0.0001) and increased by loperamide (674 +/- 267 versus 501 +/- 131 minutes; p = 0.044).
Conclusion: We propose the salivary sample method as a validated simplification of the plasma sulfasalazine-sulfapyridine test for the measurement of orocecal transit time.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0009-9236(95)90217-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Antimicrobial agents in agricultural fertilizers produced from sewage sludge - A cause for concern?
Sci Total Environ
January 2025
University of Bath, Department of Chemistry, Bath BA2 7AY, United Kingdom; Centre of Excellence in Water-Based Early Warning Systems for Health Protection, University of Bath, Bath BA25RX, United Kingdom.
The production of organic-mineral fertilizers from sewage sludge is one of the ecological options in their management. Though, pharmaceuticals and their derivatives, which accumulate in the sludge, could be a problem due to their impacts on the environment. This manuscript aimed at better understanding of risks posed by antimicrobial agents (AAs) in sludge-based fertilizers.
View Article and Find Full Text PDFToxic effects and mechanisms of nanoplastics and sulfonamide antibiotics on Scenedesmus obliquus.
Ecotoxicol Environ Saf
January 2025
Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin 541004, China; Guangxi Collaborative Innovation Center for Water Pollution Control and Water Safety Guarantee in Karst Region.
The prevalence of nanoplastics (NPs) and sulfonamide antibiotics (SAs) in the aquatic environment is potentially harmful to the environment, and these pollutants are often present in the environment in the form of composite ones, thereby introducing more complex effects and hazards to the environment. Therefore, it is crucial to investigate the toxic effects of the individual target pollutants and their mixtures. In this study, we used Scenedesmus obliquus as the test organisms, two types of NPs: polystyrene (PS) and amine-modified (NH-PS), four SAs: sulfapyridine (SPY), sulfamethazine (SMR), sulfamethoxypyridazine (SMP), and sulfamethoxazole (SMZ), and their eight binary mixtures were examined.
View Article and Find Full Text PDFCoral-Symbiodiniaceae symbiotic associations under antibiotic stress: Accumulation patterns and potential physiological effects in a natural reef.
J Hazard Mater
January 2025
School of Marine Science and Engineering, Hainan University, Haikou 570228, China. Electronic address:
Antibiotics threaten scleractinian corals, but their accumulation patterns and physiological effects on corals in natural reefs remain unclear. This study investigated antibiotic occurrence in seawater and two coral species, Galaxea fascicularis and Pocillopora damicornis, and explored the physiological effects of bioaccumulated antibiotics in a fringing reef of the South China Sea. Nineteen antibiotic components were detected in seawater, with total antibiotic concentrations (ΣABs) ranging from 17.
View Article and Find Full Text PDFSolid phase extraction-surface enhanced Raman spectroscopy (SPE-SERS) test of antibiotic residues in Milk based on au@ MIL-101 NPs.
Food Chem
February 2025
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China. Electronic address:
A SPE-SERS method was developed for the detection of several antibiotic residues in dairy products. Gold nanoparticles (Au NPs) encapsulated with an ultrathin Cr-MIL-101 shell (Au@Cr-MIL-101 NPs) have been synthesized, and the thickness of Cr-MIL-101 shell can be precisely controlled to 3 nm. As a superior solid phase extraction (SPE) adsorbent, Cr-MIL-101 acts as a shell layer to effectively enrich antibiotics within the localized surface plasmon resonance (LSPR) field of Au NPs, which enhances the SERS signal and eliminates background interference.
View Article and Find Full Text PDFInsight into efficient degradation of pentacyclic and hexacyclic sulfonamide antibiotics by synthetic trivalent copper: Performance and mechanism.
J Environ Manage
November 2024
National and Local Joint Engineering Research Center for Ecological Treatment Technology of Urban Water Pollution, College of Life and Environmental Science, Wenzhou University, Wenzhou, 325035, China. Electronic address:
Article Synopsis
- High valent metal species like Cu(III), Mn(III), and Fe(IV) are important in breaking down pollutants, but research on Cu(III) is less developed.
- Researchers synthesized copper(III) periodate to test its effectiveness on six sulfonamide antibiotics, finding that Cu(III) can nearly fully degrade them in just 10 minutes if used in a 3:1 molar ratio.
- SAs with 6-ring structures were degraded more easily, especially when they had electron-rich groups; however, factors like pH and the presence of certain compounds influenced the degradation process.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!