Lack of a specific effect of corticotropin-releasing hormone (CRH) on plasma levels of 13,14-dihydro-15-keto-prostaglandin E2 in normal subjects.

The responses of plasma adrenocorticotrophic hormone (corticotrophin, ACTH), cortisol and 13,14-dihydro-15-keto-prostaglandin E2 (PGE2-M), a stable metabolite of prostaglandin E2 (PGE2) to i.v. injection of corticotrophin-releasing hormone (CRH) were studied in eight healthy subjects before and after a dexamethasone suppression test. We demonstrated a slight increase in PGE2-M after CRH injection in a dose that markedly augmented ACTH and cortisol levels. CRH did not produce any significant changes in ACTH, cortisol or PGE2-M after dexamethasone treatment. The results did not confirm a specific effect of CRH on PGE2 production.