A case of a 38-year male patient treated for severe Wegener's granuloma has been presented. Immunosuppressive therapy including cyclophosphamide and prednisone produced a 4-week improvement followed by relapsed with advanced organ involvement (severe cardio-respiratory and renal failure). Intensive therapy with cyclosporine A and prednisone (given intravenously and next orally) carried out for 4 months produced a favourable response with complete regression of organ involvement. Actually, the patient is living in a complete remission since 4 years, and takes no drugs since 1 year.
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