Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.7164/antibiotics.48.185 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Engineering of acyl ligase domain in non-ribosomal peptide synthetases to change fatty acid moieties of lipopeptides.
Commun Chem
January 2025
Agri-Bio Research Center, Kaneka Corporation, Takasago, Hyogo, Japan.
Cyclic lipopeptides (CLPs) produced by the genus Bacillus are amphiphiles composed of hydrophilic amino acid and hydrophobic fatty acid moieties and are biosynthesised by non-ribosomal peptide synthetases (NRPSs). CLPs are produced as a mixture of homologues with different fatty acid moieties, whose length affects CLP activity. Iturin family lipopeptides are a family of CLPs comprising cyclic heptapeptides and β-amino fatty acids and have antimicrobial activity.
View Article and Find Full Text PDFAntimicrobial Activity of Cyclic Lipopeptides and Their Role in the Host Adaptive Response to Changes in Environmental Conditions.
Int J Mol Sci
January 2025
Gause Institute of New Antibiotics, ul. Bolshaya Pirogovskaya, 11, Moscow 119021, Russia.
cyclic lipopeptides (CLP), part of the three main families-surfactins, iturins, and fengycins-are secondary metabolites with a unique chemical structure that includes both peptide and lipid components. Being amphiphilic compounds, CLPs exhibit antimicrobial activity in vitro, damaging the membranes of microorganisms. However, the concentrations of CLPs used in vitro are difficult to achieve in natural conditions.
View Article and Find Full Text PDFDJK-5, an anti-biofilm peptide, increases Staphylococcus aureus sensitivity to colistin killing in co-biofilms with Pseudomonas aeruginosa.
NPJ Biofilms Microbiomes
January 2025
Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Chronic infections represent a significant global health and economic challenge. Biofilms, which are bacterial communities encased in an extracellular polysaccharide matrix, contribute to approximately 80% of these infections. In particular, pathogens such as Pseudomonas aeruginosa and Staphylococcus aureus are frequently co-isolated from the sputum of patients with cystic fibrosis and are commonly found in chronic wound infections.
View Article and Find Full Text PDFDiversification of Lipopeptide Analogues Drives Versatility in Biological Activities.
J Agric Food Chem
January 2025
Instituto de Hortofruticultura Subtropical y Mediterránea La Mayora, Universidad de Málaga-Consejo Superior de Investigaciones Científicas, Departamento de Microbiología, Universidad de Málaga, Málaga 29071, Spain.
Article Synopsis
- Cyclic lipopeptides (CLPs) are important secondary metabolites with different biological activities, primarily produced in three families: iturins, fengycins, and surfactins, each consisting of cyclic peptides attached to fatty acids.
- The study focused on isolating and analyzing various CLP variants from the strain UMAF6639, testing their effects on antifungal activity and promoting plant growth, revealing that both these effects depend on the specific lipopeptide variant and its concentration.
- The research highlights a balance in the abundance and toxicity of these variants, showing that less abundant toxic variants can work synergistically with more abundant, less toxic ones, while also contributing to increased bacterial populations and bioactivity, which could lead to sustainable agricultural
Investigation of the anti-Huanglongbing effects using antimicrobial lipopeptide and phytohormone complex powder prepared from MG-2 fermentation.
Front Microbiol
December 2024
National Key Laboratory of Germplasm Innovation and Utilization of Horticultural Crops, National Fruit Free-Virus Germplasm Resource Indoor Conservation Center, Department of Horticulture and Forestry, Huazhong Agricultural University, Wuhan, China.
Global citrus production has been severely affected by citrus Huanglongbing (HLB) disease, caused by Candidatus Liberibacter asiaticus (Clas), and the development of effective control methods are crucial. This study employed antimicrobial lipopeptide and phytohormone complex powder (L1) prepared from the fermentation broth of the endophytic plant growth promoting bacterium (PGPB) of strain MG-2 to treat Liberibacter asiaticus (Las)-infected ' 'Chun Jian' plants. Real-time fluorescence quantitative polymerase chain reaction (qPCR) and PCR were employed for disease detection.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!