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A bridge over troubled water: reverse osmosis to maintain patient care in a boil water notice.
Infect Control Hosp Epidemiol
January 2025
Department of Internal Medicine, Baystate Medical Center, Springfield, MA, USA.
A citywide boil water notice necessitated an alternative solution for treating contaminated water. We report our experience using portable reverse osmosis machines to treat the municipal water to provide purified water to patient care areas where non-sterile water was needed, preventing interruptions in services like elective surgeries.
View Article and Find Full Text PDFTherapeutic strategies: Bioactive hydrogels oxidized sodium alginate/strontium/betamethasone for preventing intrauterine adhesion.
Int J Biol Macromol
January 2025
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China. Electronic address:
Intrauterine adhesion (IUA) is an endometrial damage repair disorder that leads to menstrual loss, amenorrhea, and infertility in women; therefore, addressing this dilemma is a critical challenge. In this study, a multifunctional hydrogel, comprising oxidized sodium alginate (OSA), strontium carbonate (SrCO), and betamethasone 21-phosphate sodium (BSP), was formulated to facilitate angiogenesis, reduce fibrosis, and support tissue repair in the treatment of IUA. The composite hydrogels showed significant bioactivity on human endometrial stromal cells (HESCs) and human umbilical vein endothelial cells (HUVECs), promoting the injured HESCs repair, reversing the degree of fibrosis to a certain extent, and enhancing the proliferation and migration of HUVECs.
View Article and Find Full Text PDFSystematic Review of the Impact of Calcium Channel Blockers on Sperm Function.
Reprod Toxicol
January 2025
Department of Urology, University of Florida, Gainesville, FL 32610, USA.
This study explores the effects of calcium channel blockers (CCBs) on sperm function, a critical aspect of male fertility. Male infertility, responsible for 30-50% of infertility cases, often involves issues with sperm motility and capacitation, both of which are heavily influenced by calcium ions and specific ion channels like CatSper and voltage-dependent calcium channels (VDCCs). CCBs, which are commonly prescribed for cardiovascular conditions, inhibit these calcium channels, potentially disrupting sperm function.
View Article and Find Full Text PDFMetformin reverses infertility in a mouse model of endometriosis: unveiling disease pathways and implications for future clinical approaches.
Reprod Biomed Online
October 2024
Department of Biomedicine Experimental Biology Unit, Faculty of Medicine of the University of Porto, Porto, Portugal.; Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal.. Electronic address:
Research Question: Does metformin reverse endometriosis-associated infertility?
Design: Endometriosis was induced by transplanting uterus fragments from B6CBAF1 mice into recipients of the same strain. The mice were divided into groups: endometriosis (End, n = 24), sham-operated (Sham, n = 12), endometriosis with metformin (0.5mg/ml) orally administered for 3 months (EndMet, n = 21) and sham-operated metformin-treated (ShamMet, n = 16).
Malaria: Factors affecting disease severity, immune evasion mechanisms, and reversal of immune inhibition to enhance vaccine efficacy.
PLoS Pathog
January 2025
Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland, United States of America.
Malaria is a complex parasitic disease caused by species of Plasmodium parasites. Infection with the parasites can lead to a spectrum of symptoms and disease severity, influenced by various parasite, host, and environmental factors. There have been some successes in developing vaccines against the disease recently, but the vaccine efficacies require improvement.
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