A simple method for the measurement of 5-fluorocytosine in the presence of amphotericin B is described. The antifungal activity of amphotericin B is abolished by heating serum at 100 C for 45 min. 5-Fluorocytosine is unaffected by this treatment, and serum levels can be subsequently assayed by either tube dilution or disk diffusion methods.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC429539 | PMC |
| http://dx.doi.org/10.1128/AAC.9.3.381 | DOI Listing |
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