AI Article Synopsis

  • Twenty male subjects with strong hypoxic ventilatory responses participated in a study to analyze their ventilation under various conditions of hypoxia and drug influence.
  • Isoflurane significantly reduced the initial increase in ventilation during sustained isocapnic hypoxia, while domperidone increased this initial response without affecting the later ventilatory decline.
  • There was no interaction between isoflurane and domperidone, confirming that isoflurane suppresses the initial hypoxic response and domperidone counters this effect without altering the subsequent decline in ventilation.

Article Abstract

Twenty normal male subjects with brisk hypoxic ventilatory responses were recruited and ventilatory responses to sustained isocapnic hypoxia (SaO2 80.4 (SD 1.3)% for 20 min) were studied on separate days under four conditions: hypoxia alone, with or without domperidone, and 0.1 MAC of end-tidal isoflurane, with or without domperidone. Ventilatory variables were subjected to analysis of variance with estimation of the effects of isoflurane and domperidone, and their interaction. Isoflurane reduced the initial increase in ventilation significantly by 3.12 (95% confidence limits 1.69, 4.55) litre min-1 (P < 0.05) and domperidone increased the initial increase in ventilation by 1.78 (0.35, 3.21) litre min-1 (P < 0.05). Neither isoflurane nor domperidone affected the subsequent ventilatory decline. No interaction was found between these agents. These results confirm that 0.1 MAC of isoflurane suppressed the initial hypoxic ventilatory response but not the subsequent ventilatory decline when hypoxia was sustained. Domperidone offset the suppressive effect of isoflurane on the hypoxic ventilatory response but no interaction was detected.

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http://dx.doi.org/10.1093/bja/74.2.134DOI Listing

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