In vitro susceptibility of Mycobacterium leprae to two bipyridyl analogs was studied by using two biochemical parameters to measure the metabolic activity of the organism. VUF-8514 at 0.16 micrograms/ml, but not VUF-8842, completely inhibited the metabolic activity of M. leprae, and the action was bactericidal. When compared to rifampin (MIC 0.3 micrograms/ml), VUF-8514 was equally bactericidal against M. leprae.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC188306 | PMC |
| http://dx.doi.org/10.1128/AAC.38.12.2908 | DOI Listing |
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