Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1152/ajprenal.1993.265.3.F461 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical characteristics of anti-myelin oligodendrocyte glycoprotein antibody among aquaporin-4 negative neuromyelitis optica spectrum disorders in Egyptian patients.
Sci Rep
January 2025
Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Abassia, Cairo, Egypt.
Some patients with neuromyelitis optica spectrum disorder (NMOSD)-like symptoms test negative for anti-aquaporin-4 (anti-AQP4) antibodies. Among them, a subset has antibodies targeting myelin oligodendrocyte glycoprotein (MOG), a condition now termed MOG antibody-associated disease (MOGAD). MOGAD shares features with NMOSD, like optic neuritis and myelitis, but differs in pathophysiology, clinical presentation, imaging findings, and biomarkers.
View Article and Find Full Text PDFPromoter of Vegetable Pea Responds to Abiotic Stresses in Transgenic Tobacco.
Int J Mol Sci
December 2024
Key Laboratory of Vegetable Legumes Germplasm Enhancement and Molecular Breeding in Southern China of Ministry of Agriculture and Rural Affairs, Institute of Vegetables, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
Plasma membrane intrinsic proteins (PIPs), one sub-family of aquaporins (AQPs), are responsible for plant abiotic stress responses. However, little information is currently available about the stress responsiveness of the promoter in vegetable pea. In the present study, one novel promoter of which shared high similarity to the -type from other plants, was isolated.
View Article and Find Full Text PDFFrequency, characteristics, and immunological accompaniments of ataxia in anti-NMDAR antibody-associated encephalitis.
Front Immunol
December 2024
Department of Neurology, University Hospital Ulm, Ulm, Germany.
Introduction: Very rarely, adult NMDAR antibody-associated encephalitis (NMDAR-E) leads to persistent cerebellar atrophy and ataxia. Transient cerebellar ataxia is common in pediatric NMDAR-E. Immune-mediated cerebellar ataxia may be associated with myelin oligodendrocyte glycoprotein (MOG), aquaporin-4 (AQP-4), kelch-like family member 11 (KLHL11), and glutamate kainate receptor subunit 2 (GluK2) antibodies, all of which may co-occur in NMDAR-E.
View Article and Find Full Text PDFAMPK protects proximal tubular epithelial cells from lysosomal dysfunction and dedifferentiation induced by lipotoxicity.
Autophagy
December 2024
Laboratory of Metabolic and Molecular Biochemistry, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, University of Mons, Mons, Belgium.
Renal proximal tubules are a primary site of injury in metabolic diseases. In obese patients and animal models, proximal tubular epithelial cells (PTECs) display dysregulated lipid metabolism, organelle dysfunctions, and oxidative stress that contribute to interstitial inflammation, fibrosis and ultimately end-stage renal failure. Our research group previously pointed out AMP-activated protein kinase (AMPK) decline as a driver of obesity-induced renal disease.
View Article and Find Full Text PDFSalivary gland protective and antiinflammatory effects of genistein in Sjögren's syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha.
Cell Mol Biol Lett
December 2024
School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, 510140, China.
Article Synopsis
- - The study investigates how genistein can potentially treat Sjögren's syndrome (SS) by targeting the genistein-estrogen receptor alpha (ERα) complex, which regulates the X-inactive specific transcript (Xist) and impacts ferroptosis through acyl-CoA synthetase long-chain family member 4 (ACSL4) in salivary gland epithelial cells (SGECs).
- - Researchers used nondiabetic obese (NOD)/LtJ mice and treated SGECs with Interferon-γ to evaluate changes in symptoms like dry mouth and to examine pathological lesions and molecular mechanisms underlying SS.
- - Results showed that genistein reduced SS symptoms by increasing Xist expression and decreasing Acsl
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!