AI Article Synopsis
- Oral administration of the vaccinia virus in animals like rabbits, guinea pigs, and monkeys led to a milder immune response compared to dermal administration, with less disruption to homeostasis and more effective immunity.
- Results from revaccination in adults with an oral smallpox vaccine in Ethiopia indicated that this method is safe, effective, and has fewer side effects than the dermal route.
- A study comparing oral and dermal vaccines showed that oral vaccination had benefits such as lower environmental risk and reduced common reactions, while maintaining similar levels of immunity.
Article Abstract
Oral and dermal administrations of vaccinia virus into rabbits, guinea pigs, and monkeys demonstrated a milder (without homeostasis disturbance) course of the vaccinal process with oral immunization, intensive immunity forming in minimal sensitization of the body was compared with dermal one. The results of revaccination in adults with oral smallpox vaccine and primary immunization in Ethiopia showed that oral immunization with vaccinia virus was safe, effective and lowly reactogenic. The comparative study of the preparation in remote revaccination (5 or more years later) proved its advantage over dermal vaccine. It consists in ecological safety (vaccinia virus excretion into the environment during 1 and 11 days, respectively, by 10-fold concentration reduction), reactogenicity (5 and 33% of common reactions, respectively) in the same immunogenicity.
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