Forty-eight patients with non-resectable cancer of the oesophagus and oesophagogastric junction (group A: Stage I/II: n = 32; group B: Stage III/IV: n = 16) underwent intralumenal iridium-192 high dose-rate afterloading brachytherapy (5-7 Gy/session, total dose 5-21 Gy, mean 12.4 Gy) and external beam irradiation (Karnofsky > or = 80%: 50-60 Gy/2 Gy per day; Karnofsky 60%-79%: 30 Gy/3 per day). Prolonged satisfactory palliation (intake of at least semi-solid food) was demonstrated in 96% of patients. The mean survival for group A was 19.1 months and that for group B 6.9 months, with a 12-month survival rate of 66% for group A and 0% for group B (P < 0.001). Local tumour response and complication rate were significantly dose related with a predicted response rate of 70.5% and a complication rate of 50% at extrapolated response dose (ERD) 129.3 GY3 (Gy at alpha/beta = 3).
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http://dx.doi.org/10.1016/s0936-6555(05)80314-0 | DOI Listing |
Med Phys
January 2025
Department of Radiation Oncology, Inha University Hospital, Incheon, Republic of Korea.
Background: High-dose-rate (HDR) brachytherapy using Iridium-192 as a radiation source is widely employed in cancer treatment to deliver concentrated radiation doses while minimizing normal tissue exposure. In this treatment, the precision with which the sealed radioisotope source is delivered significantly impacts clinical outcomes.
Purpose: This study aims to evaluate the feasibility of a new four-dimensional (4D) in vivo source tracking and treatment verification system for HDR brachytherapy using a patient-specific approach.
J Contemp Brachytherapy
June 2024
Department of Medical Physics, German Oncology Center, University Hospital of the European University, Limassol, Cyprus.
Purpose: The aim of this study was a retrospective dosimetric comparison of iridium-192 (Ir) high-dose-rate (HDR) interstitial brachytherapy plans using model-based dose calculation algorithm (MBDCA) following TG-186 recommendations and TG-43 dosimetry protocol for breast, head-and-neck, and lung patient cohorts, with various treatment concepts and prescriptions.
Material And Methods: In this study, 59 interstitial Ir HDR brachytherapy cases treated in our center (22 breast, 22 head and neck, and 15 lung) were retrospectively selected and re-calculated with TG-43 dosimetry protocol as well as with Acuros BV dose calculation algorithm, with dose to medium option based on computed tomography images. Treatment planning dose volume parameter differences were determined and their significance was assessed.
J Contemp Brachytherapy
August 2024
Department of Radiation Oncology, Indraprastha Apollo Hospital, New Delhi, India.
Purpose: The present study evaluated the dosimetric impact and compared the dose variations between the advanced collapsed cone engine (Task Group 186) and Task Group 43 plans for cervical cancer using tandem and ovoid applicators.
Material And Methods: Thirty cervical cancer patients underwent iridium-192 (Ir) high-dose-rate (HDR) intra-cavitary brachytherapy using tandem and ovoid applicator. Original treatment plans for all patients were created using TG-43 dose calculation formalism.
J Contemp Brachytherapy
August 2024
Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
Purpose: For cervical cancer patients, intra-cavitary brachytherapy (ICBT) is utilized with various dose-rate systems, such as low-dose-rate (LDR), high-dose-rate (HDR), and pulsed-dose-rate (PDR). This retrospective analysis aimed to compare the therapeutic outcomes of cervical cancer patients treated with either LDR-, HDR-, or PDR-ICBT.
Material And Methods: A total of 613 patients were treated with pelvic external beam radiation therapy (EBRT), followed by either LDR- (271 patients), HDR- (259 patients), or PDR- (83 patients) ICBT.
J Contemp Brachytherapy
August 2024
Department of Oncology and Radiotherapy, University Clinical Centre in Gdan,sk, Gdan,sk, Poland.
A case report of non-classical treatment choice for mycosis fungoides (MF) presented on the left upper eyelid and forehead. Superficial brachytherapy using 3D technique was prescribed to preserve the lens's functionality, and successfully eliminate malignant lesion. Treatment was conducted with high-dose-rate (HDR) brachytherapy using iridium-192 (Ir) source as a base and Flexitron device as an afterloader.
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