AI Article Synopsis
- The study investigated how well a chelating agent called MeOBDCG removed cadmium deposits from young and older rats.
- In suckling rats, the chelation reduced cadmium retention in the whole body, liver, and kidneys to 63%, 42%, and 71% of control values, while older rats showed even greater reductions, especially in the liver at 17%.
- The findings suggest that age significantly affects the effectiveness of chelation therapy, with older rats benefiting more from the treatment, particularly in the liver.
Article Abstract
The efficiency of chelating agents to remove aged intracellular deposits of cadmium in young and older rats was studied. The administration of the chelating agent sodium N-(4-methoxybenzyl)-D-glucamine-N-carbodithioate monohydrate (MeOBDCG) 2 wk after a single intraperitoneal 115m Cd administration reduced the whole body, liver, and kidney retention in suckling rats to about 63, 42, and 71 percent and in older rats to 39, 17, and 76 percent of values obtained in respective controls. Chelation therapy was generally more effective in older than younger rats and the age-related effect was most pronounced in the liver. These results indicate that specific features of young organisms may significantly alter the effect of chelation treatment.
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| http://dx.doi.org/10.1007/BF02783790 | DOI Listing |
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