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The effect of exosomes from canine bone mesenchymal stem cells on IL-1β-mediated inflammatory responses in chondrocytes.
Cytotechnology
February 2025
College of Veterinary Medicine, Qingdao Agricultural University, No. 700 Changcheng Road, Chengyang, Qingdao, 266109 China.
Osteoarthritis is a degenerative disease of cartilage, and exosome derived from mesenchymal stem cells (MSCs) are considered promising for treating inflammatory musculoskeletal disorders, although their mechanisms are not fully understood. This study aimed to investigate the effects of exosomes derived from canine bone marrow mesenchymal stem cells (cBMSCs-Exos) on the expression of inflammatory factors and genes related cartilage matrix metabolism in IL-1β-induced canine chondrocytes. Canine BMSCs were isolated and characterized for surface markers and trilineage differentiation.
View Article and Find Full Text PDFThermo-responsible PNIPAM-grafted polystyrene microspheres for mesenchymal stem cells culture and detachment.
Biomed Mater
October 2024
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.
The preparation of cells is a critical step in cell therapy. To ensure the effectiveness of cells used for clinical treatments, it is essential to harvest adherent cells from the culture media in a way that preserves their high viability and full functionality. In this study, we developed temperature-responsive poly(N-isopropylacrylamide) (PNIPAM)-grafted polystyrene (PS) microspheres using reversible addition-fragmentation chain transfer polymerization.
View Article and Find Full Text PDFThe cartilage growth plates in the bones of children enable limb lengthening but are weak relative to the bone, making them prone to fracturing when bones are overloaded. Better treatments for severely fractured growth plates are needed because the response to injury is a bony bridge that prematurely fuses the growth plate, leading to stunted and/or crooked limbs. Murine models of growth plate injury are advantageous for mechanistic studies, but are challenging because it is difficult to visualize and precisely injure the small growth plates in young mice.
View Article and Find Full Text PDFAnti-Inflammatory and Anti-(Lymph)angiogenic Properties of an ABCB5+ Limbal Mesenchymal Stem Cell Population.
Int J Mol Sci
September 2024
Department of Ophthalmology, Faculty of Medicine, University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Article Synopsis
- Corneal transparency and avascularity are crucial for clear vision, with a transition to vascularized conjunctiva at the limbus.
- This study identifies a specific sub-population of limbal stromal cells expressing ABCB5, which exhibit mesenchymal stem cell traits and show potential for pluripotency and multi-lineage differentiation.
- ABCB5+ cells demonstrate lower levels of pro-inflammatory and pro-angiogenic factors, suggesting they could help reduce inflammation and neovascularization in the cornea, with potential implications for therapeutic applications elsewhere in the body.
Anti-Inflammatory Potency of Human Wharton's Jelly Mesenchymal Stem Cell-Derived Exosomes on L2 Cell Line Induced by Lipopolysaccharides.
Adv Pharm Bull
July 2024
School of Life Sciences and Technology, Institut Teknologi Bandung, Jl. Ganesha No.10, Bandung 40132, Indonesia.
Purpose: At present, therapeutic interventions to treat acute lung injury (ALI) remain largely limited to lung-protective strategies, as no real molecular-driven therapeutic intervention has yet become available. The administration of bacterial lipopolysaccharides (LPS) is known as an inflammatory activator, representing a frequently used model of ALI. This study investigated the biological function of normoxic (21% O ) vs.
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