The authors investigated immunological parameters during treatment with risperidone and recorded a reduction of IgG and IgM after 24 weeks of treatment. With this finding corresponded a reduced IgG synthesis, but not IgM synthesis, investigated in vitro. It was thus revealed that risperidone does not exert an immunological effect. In the course of treatment changes of immune parameters were recorded which can be, however, explained by immunological aspects of the course of the disease. The role of the antagonist of 5HT receptors is very complicated and cannot be explained by a single mechanism.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
[Clinical and immunological relationships in patients with early schizophrenia].
Zh Nevrol Psikhiatr Im S S Korsakova
March 2025
Psycho-Neurological Dispensary No. 1, St. Petersburg, Russia.
Objective: To study clinical and immunological relationships in patients with early schizophrenia during remission.
Material And Methods: Forty-eight patients (53% females and 47% males) were examined at the initial stage of schizophrenia during remission (age 28.3±5.
Effects of valproic acid, levetiracetam, carbamazepine, lamotrigine, and topiramate on LIF, E-cadherin, and FOXO1 mediator molecules in rat embryo implantation.
Food Chem Toxicol
May 2025
Department of Pediatric Neurology, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye. Electronic address:
Background: This study investigated the effects of valproic acid (VPA), levetiracetam (LEV), carbamazepine (CBZ), lamotrigine (LTG), and topiramate (TPM) on LIF, E-cadherin, and FOXO1 mediator molecules during implantation in rat embryos.
Materials And Methods: Sixty female rats were divided into six experimental groups, and the control solution and drugs were administered by gavage for 90 days. At the end of three months, implantation sites were obtained, and histological and immunohistochemical staining protocols were applied.
Unlocking the molecular mechanisms of anticancer and immunomodulatory potentials of cariprazine in triple negative breast cancer.
Biomed Pharmacother
March 2025
Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozar Markovic 69, Kragujevac 34000, Serbia; Department of Medical Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića, 69, Kragujevac 34000, Serbia. Electronic address:
Triple-negative breast cancer (TNBC), a highly invasive type of cancer, is difficult to treat due to insufficient specific targets and low survival rates. Current therapy often encounters drug resistance or relapse; thus, repurposing existing drugs could revolutionize cancer treatment. This study examined the anticancer effects of the antipsychotics Cariprazine (CAR), Olanzapine (OLZ), and Clozapine (CLZ), and the immunomodulatory potential of CAR, in vitro and in vivo in TNBC models.
View Article and Find Full Text PDFSchizophrenia is a chronic mental disorder and one of the main causes of disability in the world. Approximately 1% of the general population suffers from this disorder, and almost 30% of cases are unresponsive to antipsychotic therapies. Clozapine is a Food and Drug Administration (FDA)-approved antipsychotic drug for treatment-resistant schizophrenia (TRS).
View Article and Find Full Text PDFPredicting antipsychotic responsiveness using a machine learning classifier trained on plasma levels of inflammatory markers in schizophrenia.
Transl Psychiatry
February 2025
North Region, Institute of Mental Health, Singapore, Singapore.
We apply machine learning techniques to navigate the multifaceted landscape of schizophrenia. Our method entails the development of predictive models, emphasizing peripheral inflammatory biomarkers, which are classified into treatment response subgroups: antipsychotic-responsive, clozapine-responsive, and clozapine-resistant. The cohort comprises 146 schizophrenia patients (49 antipsychotics-responsive, 68 clozapine-responsive, 29 clozapine-resistant) and 49 healthy controls.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!