Structural requirements for the development of potent N-methyl-D-aspartic acid (NMDA) receptor antagonists.

Biochem Pharmacol

Department of Chemistry, Parke-Davis Pharmaceutical Research, Warner-Lambert Co., Ann Arbor, MI 48105.

Published: April 1993

Download full-text PDF

Source
http://dx.doi.org/10.1016/0006-2952(93)90294-7DOI Listing

Publication Analysis

Top Keywords

structural requirements
4
requirements development
4
development potent
4
potent n-methyl-d-aspartic
4
n-methyl-d-aspartic acid
4
acid nmda
4
nmda receptor
4
receptor antagonists
4
structural
1
development
1

Similar Publications

Background: One of the best ways to impart important skills to trainees is through simulation-based training, which is more reliable than the conventional clinical examination method. It is used in pediatric nursing training to allow nurses to practice and improve their clinical and conversational skills during an actual child encounter. A heel-prick is a complex psychomotor task that requires skill and knowledge from the pediatric nurse performing the procedure while applying for the National Newborn Screening Program.

View Article and Find Full Text PDF

Background: Fungal pretreatment for partial separation of lignocellulosic components may reduce lignocellulose recalcitrance during the production of biofuels and biochemicals. Quantitative and qualitative modification of plant lignin through genetic engineering or traditional breeding may also reduce the recalcitrance. This study was conducted to examine the effects of combining these two approaches using three white rot fungi and mulberry wood with an altered lignin structure.

View Article and Find Full Text PDF

Background: While most Danish citizens never or very rarely call the national emergency helpline, 1-1-2, a few citizens call very often. In this article, we attend to the often-unheard voices of frequent callers, exploring why these citizens call 1-1-2 and why they often do not feel helped.

Methods: The article is based on a mixed-methods study on citizens in the Central Denmark Region who had called 1-1-2 five or more times during a period of six months in 2023.

View Article and Find Full Text PDF

Imaging of elbow entrapment neuropathies.

Insights Imaging

January 2025

IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Entrapment neuropathies at the elbow are common in clinical practice and require an accurate diagnosis for effective management. Understanding the imaging characteristics of these conditions is essential for confirming diagnoses and identifying underlying causes. Ultrasound serves as the primary imaging modality for evaluating nerve structure and movement, while MRI is superior for detecting muscle denervation.

View Article and Find Full Text PDF

Resolving the molecular basis of a Mendelian condition remains challenging owing to the diverse mechanisms by which genetic variants cause disease. To address this, we developed a synchronized long-read genome, methylome, epigenome and transcriptome sequencing approach, which enables accurate single-nucleotide, insertion-deletion and structural variant calling and diploid de novo genome assembly. This permits the simultaneous elucidation of haplotype-resolved CpG methylation, chromatin accessibility and full-length transcript information in a single long-read sequencing run.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!